Can I set global preferences that are accessible via "Edit"->"Preferences" programmatically from within a notebook?
As learned from this question, turning off anti-aliasing can make a huge difference in the maximum allowable ImageSize. This can be done via menu:

The slider is setting the value of HardwareAntialiasingQuality that can be found with the option inspector:

Question: Is there a way to set/reset the value of HardwareAntialiasing (and others) programmatically? I´d like to set this with a line only in those notebooks that benefit from this setting and have proper antialiasing for the rest.
Footnote: this answer does help with setting the rendering method directly within a Graphics3D expression, and as @Sjoerd's answer shows this also works in more global way.