It depends on the context.
If this is part of a piece of text, then you might consider Peter Grill's suggestion:
$\exists a\in\mathbb{R}$, $\exists b\in\mathbb{R}$,
$\forall c\in\mathbb{R}$, and $\forall b\in\mathbb{R}$

On the other hand, if the quantifiers are part of a logical formula, you might consider a dot between the quantifiers, like this:
$\exists a\in\mathbb{R}\ldotp\exists b\in\mathbb{R}\ldotp
\forall c\in\mathbb{R}\ldotp\forall b\in\mathbb{R}\ldotp P$

This dot notation is inherited, I think, from Russell and Whitehead's Principia Mathematica, and is quite widely used, particularly in computer science. A comma between quantifiers is quite unusual, though it does appear in the syntax of the Coq theorem prover.
$\exists a\in\mathbb{R}, \exists b\in\mathbb{R},
\forall c\in\mathbb{R}, \forall d\in\mathbb{R}, P$

The comma notation becomes awkward when you want to quantify several variables at the same time, because then you have two different types of comma in the same formula:
$\exists a,b\in\mathbb{R}, \forall c,d\in\mathbb{R}, P$

In such cases, you might consider putting just a space between the variables, like this:
$\exists a\;b\in\mathbb{R}, \forall c\;d\in\mathbb{R}, P$

The idea of putting spaces between variables, rather than commas, is taken from the syntax of the Isabelle theorem prover.
$\exists a\in\mathbb{R}$, $\exists b\in\mathbb{R}$, $\forall c\in\mathbb{R}$, and $\forall b\in\mathbb{R}$, or perhaps$\exists a, b \in\mathbb{R}$, $\forall c, d \in\mathbb{R}$. – Peter Grill May 21 '13 at 19:02$\exists a\in\mathbb{R}\ \exists b\in\mathbb{R}$can help. I agree with @percusse though. – marczellm May 21 '13 at 19:19\let\existstemp\exists \renewcommand*{\exists}{\existstemp\mkern1mu}(I don't exactly remember the space, I wrote the1muas an example). – Manuel May 21 '13 at 19:21\displaymath, e.g. in definitions, I think is clearer (and easy to remember) to write the symbols. – Manuel May 21 '13 at 19:23