\documentclass[parskip]{scrartcl}
\usepackage[margin=15mm]{geometry}
\usepackage{tikz}
\newcommand{\block}[2][0,0]{%
\node[draw,minimum height=1cm,minimum width=3cm] (#2) at (#1) {#2};
}
\newcommand{\connector}[2]{%
\draw (#1) -- (#2);
}
\begin{document}
\begin{tikzpicture}
\block{First Block}
\block[4,-1]{Second Block}
\block[3,2]{Third Block}
\block[1,4]{Fourth Block}
\connector{First Block}{Second Block}
\connector{Third Block}{Second Block}
\connector{First Block}{Fourth Block}
\end{tikzpicture}
\end{document}

P.S. For fitting nodes in Boxes, have a look at the fitting library (chapter 34 in the manual)
Edit 1: A little more advanced, now with options for the connectors, folder like nodes and using the fitting library for the big folder nodes:
\documentclass[parskip]{scrartcl}
\usepackage[margin=15mm]{geometry}
\usepackage{tikz}
\usetikzlibrary{arrows,fit}
\usepackage{xifthen}
\usepackage{xparse}
\newcommand{\block}[2][0,0]{%
\node[draw,minimum height=1cm,minimum width=3cm] (#2) at (#1) {#2};
}
%\newcommandx{\connector}[4][1=s,2=black]{% (s,hv,vh,bl,br), arrows and line options, start, end
\DeclareDocumentCommand\connector{ O{s} m O{->} m }{
\ifthenelse{\equal{#1}{s}}{\draw[#3] (#2) -- (#4);}{}
\ifthenelse{\equal{#1}{hv}}{\draw[#3] (#2) -| (#4);}{}
\ifthenelse{\equal{#1}{vh}}{\draw[#3] (#2) |- (#4);}{}
\ifthenelse{\equal{#1}{bl}}{\draw[#3] (#2) to[bend left=45] (#4);}{}
\ifthenelse{\equal{#1}{br}}{\draw[#3] (#2) to[bend right=45] (#4);}{}
}
\newcommand{\smallblock}[2][0,0]{
\node[draw,minimum height=1.5cm,minimum width=3.5cm] (#2) at (#1) {#2};
\node[above right,minimum height=0.5cm,minimum width=1cm] (#2_1) at (#2.north west) {};
\draw (#2_1.south west) -- (#2_1.north west) -- (#2_1.north east) -- (#2_1.south east);
}
\newcommand{\bigblock}[2]{
\node[draw,minimum height=2.5cm,minimum width=4.5cm,fit=#1,inner sep=1cm] (#2) {};
\node[above right,minimum height=0.5cm,minimum width=1cm] (#2_1) at (#2.north west) {#2};
\draw (#2_1.south west) -- (#2_1.north west) -- (#2_1.north east) -- (#2_1.south east);
}
\begin{document}
\begin{tikzpicture}
\smallblock{First Block}
\smallblock[5,0]{Second Block}
\smallblock[5,-3]{Third Block}
\smallblock[0,9]{Fourth Block}
\smallblock[5,9]{Fifth Block}
\smallblock[5,6]{Sixth Block}
\smallblock[5,12]{Seventh Block}
\connector{First Block}[->]{Second Block}
\connector[hv]{Third Block}[latex-]{First Block}
\connector{Fourth Block}{Fifth Block}
\connector[br]{Fourth Block}[<->,dotted,thick]{Sixth Block}
\connector[bl]{Fourth Block}[latex'-stealth,red,ultra thick]{Seventh Block}
\bigblock{(First Block)(Second Block)(Third Block)}{First Group}
\bigblock{(Fourth Block)(Fifth Block)(Sixth Block)(Seventh Block)}{Second Group}
\connector{First Group}[latex-latex,blue,thick]{Second Group}
\end{tikzpicture}
\end{document}
