FBXW5

FBXW5
Identifiers
Aliases	FBXW5, Fbw5, F-box and WD repeat domain containing 5
External IDs	OMIM: 609072; MGI: 1354731; HomoloGene: 8496; GeneCards: FBXW5; OMA:FBXW5 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)[1]
End	136,944,738 bp[1]
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)[2]
End	25,395,483 bp[2]
RNA expression pattern
	Top expressed in
	popliteal artery; ; gastrocnemius muscle; ; right lobe of liver; ; right coronary artery; ; left coronary artery; ; thoracic aorta; ; ascending aorta; ; left ventricle; ; body of stomach; ; right lobe of thyroid gland;
	Top expressed in
	spermatocyte; ; spermatid; ; seminiferous tubule; ; entorhinal cortex; ; superior frontal gyrus; ; saccule; ; lip; ; otic placode; ; cerebellar cortex; ; aortic valve;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; protein kinase binding; ubiquitin-protein transferase activity;
Cellular component	Cul4-RING E3 ubiquitin ligase complex; cytoplasm; SCF ubiquitin ligase complex; cytosol;
Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process; protein ubiquitination; regulation of centrosome duplication; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein polyubiquitination; regulation of mitotic nuclear division; post-translational protein modification;
	Sources:Amigo / QuickGO
Orthologs
	54461
	30839
	ENSG00000159069
	ENSMUSG00000015095
	Q969U6
	Q9QXW2
	NM_018998; NM_178225; NM_178226
	NM_013908; NM_001356407; NM_001356408
	NP_061871
	NP_038936; NP_001343336; NP_001343337
	Wikidata
View/Edit Human	View/Edit Mouse

F-box/WD repeat-containing protein 5 is a protein that in humans is encoded by the FBXW5 gene.[5]

This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene contains WD-40 domains, in addition to an F-box motif, so it belongs to the Fbw class. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene, however, they were found to be nonsense-mediated Messenger RNA decay candidates, hence not represented.[5] Well established targets of FBXW5 include TSC2[6] and SEC23B.[7]

References

GRCh38: Ensembl release 89: ENSG00000159069 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000015095 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Entrez Gene: FBXW5 F-box and WD repeat domain containing 5".
Hu J, Zacharek S, He YJ, Lee H, Shumway S, Duronio RJ, et al. (April 2008). "WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase". Genes & Development. 22 (7): 866–71. doi:10.1101/gad.1624008. PMC 2279197. PMID 18381890.
Jeong YT, Simoneschi D, Keegan S, Melville D, Adler NS, Saraf A, et al. (December 2018). "The ULK1-FBXW5-SEC23B nexus controls autophagy". eLife. 7. doi:10.7554/eLife.42253. PMC 6351106. PMID 30596474.

Cenciarelli C, Chiaur DS, Guardavaccaro D, Parks W, Vidal M, Pagano M (October 1999). "Identification of a family of human F-box proteins". Current Biology. 9 (20): 1177–9. Bibcode:1999CBio....9.1177C. doi:10.1016/S0960-9822(00)80020-2. PMID 10531035. S2CID 7467493.
Winston JT, Koepp DM, Zhu C, Elledge SJ, Harper JW (October 1999). "A family of mammalian F-box proteins". Current Biology. 9 (20): 1180–2. Bibcode:1999CBio....9.1180W. doi:10.1016/S0960-9822(00)80021-4. PMID 10531037. S2CID 14341845.
Watanabe N, Arai H, Nishihara Y, Taniguchi M, Watanabe N, Hunter T, et al. (March 2004). "M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFbeta-TrCP". Proceedings of the National Academy of Sciences of the United States of America. 101 (13): 4419–24. Bibcode:2004PNAS..101.4419W. doi:10.1073/pnas.0307700101. PMC 384762. PMID 15070733.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000159069 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000015095 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: FBXW5 F-box and WD repeat domain containing 5".

[pmid18381890-6] Hu J, Zacharek S, He YJ, Lee H, Shumway S, Duronio RJ, et al. (April 2008). "WD40 protein FBW5 promotes ubiquitination of tumor suppressor TSC2 by DDB1-CUL4-ROC1 ligase". Genes & Development. 22 (7): 866–71. doi:10.1101/gad.1624008. PMC 2279197. PMID 18381890.

[pmid30596474-7] Jeong YT, Simoneschi D, Keegan S, Melville D, Adler NS, Saraf A, et al. (December 2018). "The ULK1-FBXW5-SEC23B nexus controls autophagy". eLife. 7. doi:10.7554/eLife.42253. PMC 6351106. PMID 30596474.

FBXW5

References

Further reading