RIN1
Ras and Rab interactor 1 is a protein that in humans is encoded by the RIN1 gene.[5][6][7]
| RIN1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | RIN1, Ras and Rab interactor 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 605965; MGI: 2385695; HomoloGene: 3170; GeneCards: RIN1; OMA:RIN1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Interactions
RIN1 has been shown to interact with HRAS.[8][9]
Additionally, RIN1 binds and activates ABL family tyrosine kinases.
References
- GRCh38: Ensembl release 89: ENSG00000174791 – Ensembl, May 2017
- GRCm38: Ensembl release 89: ENSMUSG00000024883 – Ensembl, May 2017
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Han L, Wong D, Dhaka A, Afar D, White M, Xie W, et al. (Jun 1997). "Protein binding and signaling properties of RIN1 suggest a unique effector function". Proc Natl Acad Sci U S A. 94 (10): 4954–9. Bibcode:1997PNAS...94.4954H. doi:10.1073/pnas.94.10.4954. PMC 24612. PMID 9144171.
- Colicelli J, Nicolette C, Birchmeier C, Rodgers L, Riggs M, Wigler M (May 1991). "Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae". Proc Natl Acad Sci U S A. 88 (7): 2913–7. Bibcode:1991PNAS...88.2913C. doi:10.1073/pnas.88.7.2913. PMC 51350. PMID 1849280.
- "Entrez Gene: RIN1 Ras and Rab interactor 1".
- Mitin NY, Ramocki Melissa B, Zullo Alfred J, Der Channing J, Konieczny Stephen F, Taparowsky Elizabeth J (May 2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21). United States: 22353–61. doi:10.1074/jbc.M312867200. ISSN 0021-9258. PMID 15031288.
- Han L, Colicelli J (Mar 1995). "A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1". Mol. Cell. Biol. 15 (3). UNITED STATES: 1318–23. doi:10.1128/mcb.15.3.1318. ISSN 0270-7306. PMC 230355. PMID 7862125.
Further reading
- Dkaha A, Costa RM, Hu H, Irvin DK, Patel A, Kornblum HI, et al. (2003). "The RAS effector RIN1 modulates the formation of aversive memories". J. Neurosci. 23 (3): 748–757. doi:10.1523/JNEUROSCI.23-03-00748.2003. PMC 6741936. PMID 12574403.
- Trowbridge IS, Lesley J, Trotter J, Hyman R (1985). "Thymocyte subpopulation enriched for progenitors with an unrearranged T-cell receptor beta-chain gene". Nature. 315 (6021): 666–9. Bibcode:1985Natur.315..666T. doi:10.1038/315666a0. PMID 3874369. S2CID 20469621.
- Han L, Colicelli J (1995). "A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1". Mol. Cell. Biol. 15 (3): 1318–23. doi:10.1128/mcb.15.3.1318. PMC 230355. PMID 7862125.
- Afar DE, Han L, McLaughlin J, Wong S, Dhaka A, Parmar K, et al. (1997). "Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1". Immunity. 6 (6): 773–82. doi:10.1016/S1074-7613(00)80452-5. PMID 9208849.
- Tall GG, Barbieri MA, Stahl PD, Horazdovsky BF (2001). "Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1". Dev. Cell. 1 (1): 73–82. doi:10.1016/S1534-5807(01)00008-9. PMID 11703925.
- Wang Y, Waldron RT, Dhaka A, Patel A, Riley MM, Rozengurt E, et al. (2002). "The RAS Effector RIN1 Directly Competes with RAF and Is Regulated by 14-3-3 Proteins". Mol. Cell. Biol. 22 (3): 916–26. doi:10.1128/MCB.22.3.916-926.2001. PMC 133556. PMID 11784866.
- Murphy GA, Graham SM, Morita S, Reks SE, Rogers-Graham K, Vojtek A, et al. (2002). "Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21/R-Ras2-mediated transformation". J. Biol. Chem. 277 (12): 9966–75. doi:10.1074/jbc.M109059200. PMID 11788587.
- Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". J. Biol. Chem. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288.
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Hu H, Bliss JM, Wang Y, Colicelli J (2005). "RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration". Curr. Biol. 15 (9): 815–23. Bibcode:2005CBio...15..815H. doi:10.1016/j.cub.2005.03.049. PMID 15886098. S2CID 6736561.
- Zhang Y, Wolf-Yadlin A, Ross PL, Pappin DJ, Rush J, Lauffenburger DA, et al. (2005). "Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules". Mol. Cell. Proteomics. 4 (9): 1240–50. doi:10.1074/mcp.M500089-MCP200. PMID 15951569.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
- Hunker CM, Giambini H, Galvis A, Hall J, Kruk I, Veisaga M, et al. (2006). "Rin1 regulates insulin receptor signal transduction pathways". Exp. Cell Res. 312 (7): 1106–18. doi:10.1016/j.yexcr.2005.12.021. PMID 16457816.
- Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
- Senda K, Goi T, Hirono Y, Katayama K, Yamaguchi A (2007). "Analysis of RIN1 gene expression in colorectal cancer". Oncol. Rep. 17 (5): 1171–5. doi:10.3892/or.17.5.1171. PMID 17390061.
- Kong C, Su X, Chen PI, Stahl PD (2007). "Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation". J. Biol. Chem. 282 (20): 15294–301. doi:10.1074/jbc.M611538200. PMID 17403676.
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