TCF7L1

TCF7L1
Identifiers
Aliases	TCF7L1, TCF-3, TCF3, transcription factor 7 like 1
External IDs	OMIM: 604652; MGI: 1202876; HomoloGene: 7563; GeneCards: TCF7L1; OMA:TCF7L1 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)[1]
End	85,310,387 bp[1]
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)[2]
End	72,766,237 bp[2]
RNA expression pattern
	Top expressed in
	popliteal artery; ; tibial arteries; ; gastric mucosa; ; ascending aorta; ; Descending thoracic aorta; ; subcutaneous adipose tissue; ; left lobe of thyroid gland; ; canal of the cervix; ; right lobe of thyroid gland; ; right coronary artery;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; vas deferens; ; left colon; ; ankle joint; ; abdominal wall; ; ciliary body; ; dermis; ; molar; ; spermatocyte;
	More reference expression data
	n/a
Gene ontology
Molecular function	sequence-specific DNA binding; beta-catenin binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; chromatin binding;
Cellular component	transcription regulator complex; nucleus; nucleoplasm; cytosol;
Biological process	regulation of Wnt signaling pathway; chromatin organization; Wnt signaling pathway; transcription, DNA-templated; canonical Wnt signaling pathway; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; beta-catenin-TCF complex assembly;
	Sources:Amigo / QuickGO
Orthologs
	83439
	21415
	ENSG00000152284
	ENSMUSG00000055799
	Q9HCS4
	Q9Z1J1
	NM_031283
	NM_001079822; NM_009332
	NP_112573
	NP_001073290; NP_033358
	Wikidata
View/Edit Human	View/Edit Mouse

Transcription factor 7-like 1, also known as TCF7L1, is a human gene.[5]

This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence.[5]

References

GRCh38: Ensembl release 89: ENSG00000152284 – Ensembl, May 2017
GRCm38: Ensembl release 89: ENSMUSG00000055799 – Ensembl, May 2017
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
"TCF7L1 transcription factor 7 like 1 [ Homo sapiens (human) ]". Retrieved 2021-05-29.

Castrop J, van Norren K, Clevers H (Feb 1992). "A gene family of HMG-box transcription factors with homology to TCF-1". Nucleic Acids Research. 20 (3): 611. doi:10.1093/nar/20.3.611. PMC 310434. PMID 1741298.
Sagara N, Katoh M (Nov 2000). "Mitomycin C resistance induced by TCF-3 overexpression in gastric cancer cell line MKN28 is associated with DT-diaphorase down-regulation". Cancer Research. 60 (21): 5959–62. PMID 11085512.
Kim TW, Kim HJ, Lee C, Kim HY, Baek SH, Kim JH, Kwon KS, Kim JR (Apr 2008). "Identification of replicative senescence-associated genes in human umbilical vein endothelial cells by an annealing control primer system". Experimental Gerontology. 43 (4): 286–95. doi:10.1016/j.exger.2007.12.010. PMID 18258400. S2CID 37034259.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Molecular Medicine. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Katoh M (Jan 2007). "Networking of WNT, FGF, Notch, BMP, and Hedgehog signaling pathways during carcinogenesis". Stem Cell Reviews. 3 (1): 30–8. doi:10.1007/s12015-007-0006-6. PMID 17873379. S2CID 20861838.
Filleur S, Hirsch J, Wille A, Schön M, Sell C, Shearer MH, Nelius T, Wieland I (2009). "INTS6/DICE1 inhibits growth of human androgen-independent prostate cancer cells by altering the cell cycle profile and Wnt signaling". Cancer Cell International. 9: 28. doi:10.1186/1475-2867-9-28. PMC 2779787. PMID 19906297.
Balaz P, Plaschke J, Krüger S, Görgens H, Schackert HK (Aug 2010). "TCF-3, 4 protein expression correlates with beta-catenin expression in MSS and MSI-H colorectal cancer from HNPCC patients but not in sporadic colorectal cancers". International Journal of Colorectal Disease. 25 (8): 931–9. doi:10.1007/s00384-010-0959-9. PMID 20532534. S2CID 22778766.
Salins P, Shawesh S, He Y, Dibrov A, Kashour T, Arthur G, Amara F (Feb 2007). "Lovastatin protects human neurons against Abeta-induced toxicity and causes activation of beta-catenin-TCF/LEF signaling". Neuroscience Letters. 412 (3): 211–6. doi:10.1016/j.neulet.2006.07.045. PMID 17234346. S2CID 53251386.
Halatsch ME, Löw S, Mursch K, Hielscher T, Schmidt U, Unterberg A, Vougioukas VI, Feuerhake F (Aug 2009). "Candidate genes for sensitivity and resistance of human glioblastoma multiforme cell lines to erlotinib. Laboratory investigation". Journal of Neurosurgery. 111 (2): 211–8. doi:10.3171/2008.9.JNS08551. PMID 19301967.
Barker N, Huls G, Korinek V, Clevers H (Jan 1999). "Restricted high level expression of Tcf-4 protein in intestinal and mammary gland epithelium". The American Journal of Pathology. 154 (1): 29–35. doi:10.1016/S0002-9440(10)65247-9. PMC 1853446. PMID 9916915.
Velasco J, Zarrabeitia MT, Prieto JR, Perez-Castrillon JL, Perez-Aguilar MD, Perez-Nuñez MI, Sañudo C, Hernandez-Elena J, Calvo I, Ortiz F, Gonzalez-Macias J, Riancho JA (Jan 2010). "Wnt pathway genes in osteoporosis and osteoarthritis: differential expression and genetic association study". Osteoporosis International. 21 (1): 109–18. doi:10.1007/s00198-009-0931-0. PMID 19373426. S2CID 8813712.
Graham TA, Weaver C, Mao F, Kimelman D, Xu W (Dec 2000). "Crystal structure of a beta-catenin/Tcf complex". Cell. 103 (6): 885–96. doi:10.1016/S0092-8674(00)00192-6. PMID 11136974. S2CID 16865193.
Lukas J, Mazna P, Valenta T, Doubravska L, Pospichalova V, Vojtechova M, Fafilek B, Ivanek R, Plachy J, Novak J, Korinek V (May 2009). "Dazap2 modulates transcription driven by the Wnt effector TCF-4". Nucleic Acids Research. 37 (9): 3007–20. doi:10.1093/nar/gkp179. PMC 2685103. PMID 19304756.
Ollila HM, Soronen P, Silander K, Palo OM, Kieseppä T, Kaunisto MA, Lönnqvist J, Peltonen L, Partonen T, Paunio T (Apr 2009). "Findings from bipolar disorder genome-wide association studies replicate in a Finnish bipolar family-cohort". Molecular Psychiatry. 14 (4): 351–3. doi:10.1038/mp.2008.122. PMC 2694406. PMID 19308021.
Pollheimer J, Loregger T, Sonderegger S, Saleh L, Bauer S, Bilban M, Czerwenka K, Husslein P, Knöfler M (Apr 2006). "Activation of the canonical wingless/T-cell factor signaling pathway promotes invasive differentiation of human trophoblast". The American Journal of Pathology. 168 (4): 1134–47. doi:10.2353/ajpath.2006.050686. PMC 1606554. PMID 16565489.
Brantjes H, Roose J, van De Wetering M, Clevers H (Apr 2001). "All Tcf HMG box transcription factors interact with Groucho-related co-repressors". Nucleic Acids Research. 29 (7): 1410–9. doi:10.1093/nar/29.7.1410. PMC 31284. PMID 11266540.

This article is issued from Wikipedia. The text is licensed under Creative Commons - Attribution - Sharealike. Additional terms may apply for the media files.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000152284 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000055799 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "TCF7L1 transcription factor 7 like 1 [ Homo sapiens (human) ]". Retrieved 2021-05-29.

TCF7L1

References

Further reading