Normally 10,000 ft is considered safe altitude for emergency descents and 12,000 ft a maximum that can be flown in unpressurised aircraft without using supplementary oxygen.
But when flying in the mountains with a crew that normally lives at say 5,000 ft or more, can they afford higher altitude? And by how much?
Note: The 12,000 ft I've seen somewhere, but I don't know whether it is actually a regulation or just recommendation.