On a twin with a single fin and rudder, the only significant propeller wash factor is propeller P Factor, as it offsets the thrust line to the right of the propeller axis (for a clockwise-from-behind propeller).
So the right engine's net thrust line is farther away from the airplane's longitudinal axis than the left's, and more rudder is required to counter the thrust offset with the longer arm, all else being equal, which is why losing the left engine (the critical one) is a bigger deal than losing the right (along with the fact that a lot of twins had a single hydraulic pump powered off the left engine, so if you lost the left side, you had to manually retract the gear with a hand pump AND deal with the control issues, all while doing the engine-out drill - a pretty intense exercise). Of course if you have counter-rotating propellers, conditions are the same with either engine out, especially if you had dual hydraulic pumps or an electric backup pump instead of a hand one.
The spiral wake of the prop is of little significance because the wakes generally miss the fin/rudder, being off to the side.
In a plane like a Beech 18 with two fins/rudders that are directly in the propeller slipstream, you have improved rudder effectiveness because the surface is in the prop blast, and the spiral slipstream may apply its own lateral component to the fin/rudder depending on where the aerodynamic center of the surface is within the spiral flow field, that determines what the overall angle of attack of the surface is. In any case, it may help or hinder the rudder, but mostly the effect will be lost in the noise of all the other effects.
All that is going on is, the thrust line is offset, which wants to take the plane around in a flat turn, rudder is applied to stop the turn, and you end up with a resultant thrust vector, the sum of the engine's thrust and the rudder's lateral lift, slewed to one side, and the bank applied reorients the thrust vector back to being straight ahead.
The rule of thumb is 5 degrees of bank because most twins don't have yaw strings and the ball doesn't help you much, and 5 degrees is a good ballpark number that works well enough when at blueline speed. If you had a yaw string, you would just apply whatever bank it takes to align the yaw string, 4 degrees of bank, 6 degrees of bank, whatever.
Imagine taking off in a glider with the tow line connected to the wing leading edge a few feet from the fuselage. You would have tons of rudder in just trying to keep the nose pointed at the tug, but you would still slew way out to the side opposite to the tow line connection. You would have to lower the wing with the tow line connected, and at some angle, you would find the glider lined up behind the tug, with the yaw string straight, with the wings banked 5 or 7 or 10 degrees into the side that has the two rope connected.