A methyl group can be added to a cytosine residue, usually one that neighbors a guanine (known as a CpG - cytosine-phosphate-guanine - site). This can affect chromatin and histone structures, as well as directly influencing binding of various factors, thereby altering the transcription of genes.
Questions tagged [dna-methylation]
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If a promoter region of a gene is transcribed, can it get methylated?
Deletion of a transcription termination site can lead to a downstream gene's promoter region being transcribed. What if that portion of the mRNA acts like an siRNA methyltransferase recruiter?
eugheugh
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