This is a continuation to a previous question of mine regarding a change to a one-pot procedure for the preparation of Wellbutrin that I performed in college last semester. Could toluene have been used as the extraction solvent for the a-bromoketone and for the nucleophilic substitution? The procedure we were given used DCM and then removed it under vacuum for a solvent switch to NMP. Also, what was the reason for this? Could a mixture of NMP and DCM have been used?
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