So, I'm going to verify the first claim suggested by @user26857:
- If $S$ is a simple left $R$-module, then $S^n$ is a simple left $M_n(R)$-module.
We're going to show that $S^n$ has no submodules.
If we think of elements of $S^n$ as column vectors with entries in $S$, then $M_n(R)$ acts on $S^n$ by matrix multiplication from left.
If $S'$ is a submodule of $S$, then $(S')^n$, that is the set of all columns vectors with entries in $S'$ is a submodule of $S^n$. This is immediately seen from matrix multiplication.
On the other hand, if $X$ is a submodule of $S^n$, then using row operations on vectors in $S^n$, we can see that all of its rows must come from the same $R$-submodule of $S$.
Now we're going to verify the second claim:
- $\operatorname{ann}_{M_n(R)}S^n=M_n(\operatorname{ann}_RS)$
It is immediately clear from matrix multiplication that if $A$ is a matrix with entries in $\operatorname{ann}_RS$, then $AX = 0$ for all $X \in S^n$. Therefore, $M_n(\operatorname{ann}_RS) \subseteq \operatorname{ann}_{M_n(R)}S^n$
For the other direction, if $A$ is a matrix with entries in $R$, then the left multiplication by $(s,0,\dots,0), \dots ,(0,0,\dots,s)$ for all $s \in S$ show that all entries must fall in $\operatorname{ann}_RS$. Therefore $\operatorname{ann}_{M_n(R)}S^n \subseteq M_n(\operatorname{ann}_RS)$.