There are plenty of questions about the homology of the connected sum of two $n$-manifolds, but I didn't find an explicit explanation of the computation done in degree $n-1$. Let's show some examples of such questions:
1) In this question it is outlined the way to solve it, which is perfectly clear, but I don't know how to prove the result claimed in degree $n-1$.
In the comments it's written that the boundary map $$H_n(M) \to H_{n-1}(B\setminus B') = H_{n-1}(S^{n-1})$$ is an iso, but being a purely algebraic map, I cannot visualise it, and hence I don't know how to prove that it is in fact an isomorphism.
My Idea ($M,N$ orientable): if the map were induced by inclusion we would be OK, because we are mapping the fundamental class of the connected sum in a local orientation, and this is an iso. But I don't know how to formalise it properly. Moreover I don't know how to deal with the boundary map, which is purely algebraic, so not good to handle in general. In the case that one of them is not orientable, I don't know how to proceed.
2) The same problem arises in this question where there is written:
[...] In the case that both are orientable, the above sequence turns into $$0\to \mathbb{Z} \to \mathbb{Z}\oplus\mathbb{Z} \to \mathbb{Z} \to \widetilde{H}_{n-1}(M\# N)\to \widetilde{H}_{n-1}(M\vee N) \to 0$$ as their connected sum is also orientable. From this, we see that $$\widetilde{H}_{n-1}(M\# N)\to \widetilde{H}_{n-1}(M\vee N)$$ must be an isomorphism.
I'm not able to find a reason on why it is true. A similar (mutatis mutandis) result it's stated in the case that only one of them is orientable.
Here you can find the same question, with the additional "hint" that:
the so called bounding sphere is homologous to zero, (which should means that the map $H_n-1(S^n-1)$ into $H_n-1(M-p) \oplus H_n-1(N-p)$ is the zero map) .
But even here without any further references on why this result is true.
I'm starting thinking that this should be a kind of triviality, but I'm facing several problems in finding a proof of it. So can someone explain the isomorphism between $H_{n-1}(M \sharp N)$ and $H_{n-1}(M)\oplus H_{n-1}(N)$ in the cases that both manifold are orientable and only one of them is orientable?