We have, $P_1=2, P_2=3\dots$ and so on. I said this because, you should know that there is only one even prime i.e.$2$, all prime else are odd.
Now, consider the l.c.m. of $P_1, P_2,\dots ,P_n$, and call this $l$. Look at this, $l$ is an even number(it is simply $P_1\times P_2\times\dots=2\times 3\times\dots$) .
Now, consider the sum $$S=\frac l{P_1}+\frac l{P_2}+\dots+\frac l{P_n}.$$
Note that, $S$ is an odd number, because,in the summands, the only term $\frac l{P_1}$ is odd, as the factor $2$ of $l$ vanishes out, and others are even, because there the factor $2$ never vanishes.
Now, $$\frac Sl=\frac 1{P_1}+\frac 1{P_2}+\dots+\frac 1{P_n}.$$ Since $S$ is odd and $l$ is even, the fraction cannot be integer, so, your claim.