Let $R \subset S$ be an integral extension of domains and $\mathfrak p \subset R$ a prime ideal. Can it be the case that there are infinitely many distinct primes ${\cal P} \subset S$ such that ${\cal P} \cap R=\mathfrak p$?
Certainly this is impossible if $S$ is a Dedekind domain, because the primes lying over $\mathfrak p$ are the primes of $S$ occurring in the factorization of $\mathfrak p$ over $S$. I don't have much of an intuition for integral ring extensions that aren't number fields, so past this I'm not particularly sure.