I've simply said that adding $1$ to the numerator and denominator when the denominator is $5^n$ (greater than $2^n$), the "$+1$" accounts for a larger portion of the numerator than the denominator, so $\frac{2^n+1}{5^n+1}$ better be greater than$\frac{2^n}{5^n}$ for all $n\gt0$.
I'm just not satisfied with this explanation because it seems sloppy and not rigorous... Does someone have a better proof?