Marty has answered the problem of finding the original limit, which as Ted pointed out does not require the ratio test. However, in some circumstances, including this one, the ratio test does give a way to find the limit. So let's first look at your question of finding the limit of the ratio, then come back the original sequence.
As has been pointed out, it helps to note that $\dfrac{n^{100}}{(n+1)^{100}}=\left(\dfrac{n}{n+1}\right)^{100}$. It is easy to find the limit of $\dfrac{n}{n+1}$, e.g. by first writing it as $1-\dfrac{1}{n+1}$ or as $\dfrac{1}{1+\frac{1}{n}}$. Then the identity $\lim\limits_{n\to\infty} x_n^{100}=(\lim\limits_{n\to\infty} x_n)^{100}$ applies.
You should thus be able to conclude that $\lim\limits_{n\to\infty}\dfrac{a_{n+1}}{a_n}=2$, if $a_n=\dfrac{2^n}{n^{100}}$. This implies that $\lim\limits_{n\to\infty}a_n=+\infty$. Informally, the limit of the ratios being $2$ means that when $n$ is large, $a_{n+1}$ is about twice as large as $a_n$, and then $a_{n+m}\approx 2^ma_n\to\infty$ as $m\to\infty$. More formally, it implies that the sequence is eventually monotone and therefore converges to a positive real number or $+\infty$. The finite case can be ruled out by contradiction, because $\lim\limits_{n\to\infty}{a_n}=L<+\infty$ would imply that $\lim\limits_{n\to\infty}\dfrac{a_{n+1}}{a_n}=\dfrac{L}{L}=1.$ All that was required is that the limit of the ratio was greater than $1$. (If the limit of the ratio were less than $1$, the sequence would converge to $0$, and if the limit were $1$ the test would be inconclusive.)