You can construct a line through the center of the sphere
if you know the center of the projection
and if you can identify the axes of the ellipse.
Let $O$ be the center of the projection and
let $P$ and $Q$ be the endpoints of the major axis of the ellipse.
Construct the lines $OP$ and $OQ$.
These lines lie along the surface of the cone.
The plane containing these lines also contains the axis of the cone.
Bisect the angle $\angle POQ$.
Then the angle bisector is the axis of the cone and passes through
both the center of the projection and the center of the sphere.
The angle bisector of $\angle POQ$ intersects the major axis of the ellipse at a point $M$ that divides the major axis into two segments whose lengths have the ratio
$\lvert MP\rvert:\lvert MQ\rvert = \lvert OP\rvert:\lvert OQ\rvert$. This implies that $M$ is the center of the ellipse only if $\lvert OP\rvert = \lvert OQ\rvert$, in which case the ellipse is a circle.
If you know the radius and location of the sphere then it is possible to find the point $M$ using that information.
If you know only the ellipse then it is not possible to identify the point $M$ where the axis of the cone intersects the plane of the ellipse.
This is because there are infinitely many points that could be the center of a projection mapping a sphere to the given ellipse. See the answers to
From ellipse equation to circular cone axis.