When trying to answer this question I've discovered what looks like a bug in NSolve introduced in version 11.1.0.
$Version
"11.1.0 for Microsoft Windows (64-bit) (March 13, 2017)"
With setup
Clear[dBeta, solnEquation, solnFun];
dBeta[k_Integer, x_, var1_] = Derivative[k, 0][Beta[#1, #2, 2] &][x, var1];
solnEquation[var1_, var2_, x_] = Sum[Binomial[5, k]*dBeta[k, x, var1]*var2^k, {k, 0, 5}];
equation[var1_, var2_, x_] := solnEquation[var1, var2, x] == Beta[2, 2];
Solve is able to find two solutions for var1 = 2, var2 = 1/10:
sol = Solve[equation[2, 1/10, x] && 0 < x < 1, x, Reals];
equation[2, 1/10, x] /. Normal@sol // N
Solve::incs: Warning: Solve was unable to prove that the solution set found is complete.
{True, True}
While NSolve claims that there are no solutions in the real domain:
NSolve[equation[2, 1/10, x] && 0 < x < 1, x, Reals]
{}
But without this restriction it finds two solutions in the real domain:
NSolve[equation[2, 1/10, x] && 0 < x < 1, x]
equation[2, 1/10, x] /. %
{{x -> 0.328152}, {x -> 0.741041}}{True, True}
In version 11.0.1 NSolve gives correct answer for the real domain:
$Version
"11.0.1 for Microsoft Windows (64-bit) (September 20, 2016)"
NSolve[equation[2, 1/10, x] && 0 < x < 1, x, Reals]
{{x -> 0.3281517106189123`}, {x -> 0.7410414526199698`}}
Is it a bug in version 11.1.0?