Problem is to get numerical solution for equation
equ = D[c[x, y, z, t], t] - Kx * D[c[x, y, z, t], x, x] - Ky * D[c[x, y, z, t], y, y] - Kz * D[c[x, y, z, t], z, z] == 0;
c[x, y, z, t] == 0, t-> Infinity,
c[x, y, z, 0] == 0 // Assumptions -> {x != 0, y != 0, z != 0},
Integrate[Integrate[Integrate[c[x,y,z,t], {x, -Infinity, +Infinity}], {y, -Infinity, +Infinity}], {z, 0, Infinity}] == Qip
with
NDSolve[{equ,c[x, y, z, t] == 0, t-> Infinity,c[x, y, z, 0] == 0 // Assumptions -> {x != 0, y != 0, z != 0}, Integrate[Integrate[Integrate[c[x,y,z,t], {x, -Infinity, +Infinity}], {y, -Infinity, +Infinity}], {z, 0, Infinity}] == Qip}, x,y,z,t, {x,0,10}, {y,0,10}, {z,0,10}, {t, 0, 50}]
where the solution is given by
c[x_,y_,z_,t_]=Qip (4 Pi t)^1/2 exp[-1/4t (x^2/kx + y^2/ky + z^2/kz)]
and to compare with numerical