Simplify is at root an expression tree minimizer, equipped with some algebraic and logical transformations. As such, it may have the transformations needed to reach your goal, but its main goal is to apply transformations that result in smaller expression trees. It is also possible that it may not try the transformation needed to get to your goal. Functions whose purpose is to solve algebraic systems, such as Reduce, are generally more robust. They tend not to mind if all the cases to consider get quite complicated. Whereas Simplify is like a first-year university student who feels it's time to give up when things get complicated, Reduce is like a graduate student determined to impress their professor.
Expre10 = (B^2/C + 2 B + B^2/D + (B C)/D + (B D)/C) +
1 (C + D) - (A β σ)/(B C D) (C + D) /. C -> c /.
D -> d;
Assuming[{A > 0, B > 0, c > 0,
d > 0, β > 0, σ > 0,
(A β σ)/(B c d) <= 1},
Reduce[$Assumptions \[Implies] Expre10 > 0, {}, Reals]]
(* True *)
Specifying the domain Reals is key here, too.
(X > Y) > 0. To see why this is wrong, imagine doing(2 > 1) > 0which returnsTrue > 0- this is incorrect. Your Expre10 already contains a>sign and yourSimplifyis adding on this extra> 0at the end. – flinty Sep 23 '21 at 12:59CandDare protected system symbols. Best practice is to avoid single capital letters for your own variables. Recommended practice is to avoid starting your variable/function names with a captial. See https://mathematica.stackexchange.com/a/18395/4999, point 4. – Michael E2 Sep 23 '21 at 13:37{A, B, C, D}replaced by lower-case letters. Nonetheless, this is not a suitable question, because it asks (in effect), why isn't Mathematica capable of doing what I think it should, which cannot be answered except by Wolfram staff. – bbgodfrey Sep 23 '21 at 14:31