Updated
System Info: HONOR laptop AMD Ryzen 5 4600H 3Hz 6 cores 16GB Memory,
Windows 10 Pro 64 bit with updates.
Mathematica Info: Versions 12.2 and 13.2, both on the same laptop.
Examples:
p1 = RandomPolygon[{"Simple", 50}, DataRange -> {{1, 2}, {1, 2}}];
p2 = RandomPolygon[{"Simple", 50}, DataRange -> {{1, 2}, {1, 2}}];
Timing[RegionIntersection[p1, p2] === EmptyRegion[2]]
WM 12.2: 0.1-0.3 s vs WM 13.2: 3.1-3.6 s
Timing[RegionDifference[p1, p2]]
WM 12.2: 0.3-0.34 s vs WM 13.2: 3.4-3.5 s
Timing[RegionUnion[p1, p2]]
WM 12.2: 0.1-0.2 s vs WM 13.2: 0.7-0.9 s
Other operations (graphs, big numbers) do not show such differences, but I still checking.
More specific question
For one demo, I'd like to create shapes like this one:

Not too complex (without holes and self-intersections),
so the output is just simple polygon with 30-50 vertices:
bf[p_, s_] :=
BSplineFunction[p, SplineClosed -> True, SplineDegree -> s];
initialShape =
With[{pts = RandomReal[{0.2, 0.6}, {9, 2}]*CirclePoints[9]},
Polygon[Table[ bf[pts, 4][t], {t, 0, 1, 0.02}]]
];
shape[center_, size_] :=
TranslationTransform[center][
ScalingTransform[{size, size}][initialShape]];
For further I need to analyze the intersections of these figures.
The problem with RegionDisjoint has already been described here,
and in version 13.2 it still remained:
RegionDisjoint[shape[{1., 1.}, 1.], shape[{5., 5.}, 2.]]
OK, we can use RegionIntersection:
isNonIntersect[shape1_, shape2_] :=
RegionIntersection[shape1, shape2] === EmptyRegion[2];
It works, but I found big oddities with the timing of RegionIntersection:
Result:
True Version 12.2: 0.06-0.08s Version 13.2: 1.2-1.3s
False Version 12.2: 0.0s Version 13.2: 0.01-0.2s
Why does it take longer to get True, and why Mathematica 13.2 is so slow?!
(all it runs on the same laptop with Win 10)

BoundaryDiscretizeRegionorDiscretizeRegionto the polygon; as far as I know it should result equivalent region, at least for polygons with machine-precision coordinate values. Also, mesh regions tend to behave better on intersections etc. than polygons. – kirma Jan 20 '23 at 07:26SeedRandomvalue andshapespecifications. – kirma Jan 20 '23 at 07:59DiscretizeRegionruns 2-3 times slower ( – lesobrod Jan 20 '23 at 09:51RegionUnionhas drastic reduction in performance with these inputs. My numbers are not very comparable because I have to run 12.3.1 under emulation, though. It could be possible that algorithms used by these functions for polygons have had bugs fixed for better correctness and performance regressions stem from that... – kirma Jan 20 '23 at 10:09DiscretizeRegionbutBoundaryMeshRegionworks very well – lesobrod Jan 21 '23 at 07:28