This question, or rather any answer that it might receive, would probably belong to the realm of Awfully sophisticated proof for simple facts. Still, I claim that I have quite serious motivation for it.
First, the question itself. Consider the space of half-spinors in the 10-dimensional (complex) vector space $V=\mathbb C^{10}$. One of its descriptions is this. Take some non-degenerate quadratic form $q$ on $V$; let $W\subset V$ be an isotropic $5$-dimensional subspace. It generates a subalgebra in the Clifford algebra $\operatorname{Cl}_q(V)$ isomorphic to the exterior algebra $\bigwedge^*(W)$. This, if I am not mistaken, is called the algebra of pure spinors, and splits into the direct sum of two $16$-dimensional subspaces $S_\pm$ called spaces of half-spinors, namely, the even degree part $\bigwedge^{2*}(W)$ and the odd degree part $\bigwedge^{2*+1}(W)$.
The question is whether there exists a $\textsf{natural}$ isomorphism $\mathbb C^4\otimes\mathbb C^4\to S_+$ (or $\to S_-$). By "natural" you may understand what you want, but I mean something invariant, for example, not requiring to choose bases or, say, invariant under the actions of as large a group as possible.
A lightweight version: find a $\textsf{natural}$ bijection between $\{1,2,3,4\}\times\{1,2,3,4\}$ and subsets of $\{0,1,2,3,4\}$ with even number of elements.
Now, that awfully sophisticated motivation. One of the four (up to conjugation) automorphisms of order four of the simple Lie algebra $\mathfrak e_8$ is such that with respect to the induced $\mathbb Z/4\mathbb Z$-grading $\mathfrak g^1\oplus\mathfrak g^i\oplus\mathfrak g^{-1}\oplus\mathfrak g^{-i}$ of $\mathfrak e_8$, the algebra $\mathfrak g^1$ of fixed points of this automorphism is of type $\mathfrak{so}_{10}\oplus\mathfrak{sl}_4$ and its action on $\mathfrak g^i$ (which is $64$-dimensional) is via the tensor product $\mathbf{16}\otimes\mathbf 4$ of the half-spinor representation of $\mathfrak{so}_{10}$ and the standard representation of $\mathfrak{sl}_4$. What I really want to understand is this: when one classifies orbits of the action of the corresponding group on $\mathfrak g^i$, what does one really classify? If there would be some "natural" isomorphism $\mathbf 4\otimes\mathbf 4\to\mathbf{16}$, then each element of $\mathbf{16}\otimes\mathbf 4$ would give rise to some binary operation on $\mathbf 4$, and one could start studying properties of those operations which arise in this way. But maybe there is something even more interesting and less straightforward, I don't know.