I understand $E=mc^2$ calculates the amount of energy inherent in a given mass. Mass meaning "an object's resistance to acceleration (a change in its state of motion) when a net force is applied" (1) and Energy meaning "the property that must be transferred to an object in order to perform work on, or to heat, the object." (2) This Mass-energy equivalence makes more intuitive sense to me when thinking of those explicit definitions and how they are inherently related to one another and tied together through fundamental forces.
As I consider my question, I may just be unclear on the nature of mass and how it is independent of other properties. But I can't help to wonder - does a gram of sugar, a gram of soil, a gram of water, and a gram of lead all contain the same inherent amount of energy, because they are all of equal mass (or, said in a different way, because they are all of equal resistance to acceleration)? It could be that the only difference between equal masses of those materials are in other properties than their inherent Energy (for example, a gram of water and a gram of lead have different volume and conductivity).