On our el6 servers there is a quantity of unused memory while on el5 servers there was no such problem. We need to get more aggressive caching on el6 as it used to be in el5.
Munin graphs on el6:

Munin graphs on el5:

On el6 we try, but dont help:
vm.zone_reclaim_mode=0
vm.dirty_background_ratio=60
vm.dirty_ratio=80
vm.nr_pdflush_threads = 2
vm.min_free_kbytes = 19921
vm.swappiness = 5
vm.dirty_writeback_centisecs = 2250
vm.dirty_expire_centisecs = 2250
vm.vfs_cache_pressure = 1250


At first installed centos 5.9 At second installed centos 6.3
Disk activity on el5: http://i.imgur.com/zPGo4Sv.png On el6: http://i.imgur.com/4tWBjPV.png
Cpu activity on el5: http://i.imgur.com/n3Z9OoU.png on el6: http://i.imgur.com/T20eLD8.png
– Dmitriy Feb 28 '13 at 12:50