I successfully disabled this windows 10 shortcut using this guide.
Notice: using this method will disable ALL windows hotkeys that include the windows key and s. Unfortunately, as far as I know there's no way to disable a single hotkey combination.
Basically, open the registry editor, and just add a new registry key at this location:
HKEY_CURRENT_USER\Software\Microsoft\Windows\CurrentVersion\Explorer\Advanced
name the new key DisabledHotkeys and give it the value S.
Reboot your system, and the hotkey will be disabled.
Obligatory warning: Don't touch the registry editor if you don't know what you're doing. It's for advanced users, and using it incorrectly can cause major issues. Use at your own risk.
AutoHotKey. Just in case you change your mind. – Sandeep May 16 '18 at 09:02