Take this one-liner (split into multiple lines for readability) as an example:
tmux set-hook -g after-resize-pane \
'if "[ #{window_zoomed_flag} -eq 1 ]" \
"run \"tmux select-pane -P bg=red\"" \
"run \"tmux select-pane -P bg=black\""
'
Run it in a shell within tmux and zoom any pane to test the solution.
Notes:
It's pure tmux solution, it doesn't depend on iTerm2.
There are three levels of quoting (single-quotes, double-quotes, escaped double-quotes). While adjusting the command to your needs don't mix them up.
-g means the hook is global; without -g it's a session hook.
Unset the hook with tmux set-hook -gu after-resize-pane.
To make the solution permanent, add this line to ~/.tmux.conf (or /etc/tmux.conf):
set-hook -g after-resize-pane 'if "[ #{window_zoomed_flag} -eq 1 ]" "run \"tmux select-pane -P bg=red\"" "run \"tmux select-pane -P bg=black\""'