If you have a USB headset then it will be completely separate and independent from the Realtek audio system.
The Realtek devices will control the various 3.5mm sockets on your motherboard. You will most likely find them on your back panel and may also have them on the case as well:

USB devices on the other hand are distinct audio devices in their own right. They have their own drivers, both software within the operating system and hardware driving the speakers.
I cannot speak for your actual problem but judging by the "USB PnP Sound Device" I would suspect that you have a very generic USB headset and it may be that the hardware is not 100% compliant with how the generic driver is passing data to it.
Code: 0x803FB005error. Some comments say that can happen if I have the wrong drivers, but I have the version DriverEasy recommends. (Not that they'd necessarily know best.) My main concern are the comments about how the software makes all audio flaky. – Daniel Kaplan Sep 19 '23 at 23:31Nvidia also has some audio technology that you might have accidentally enabled.I definitely have those drivers. Those were the red lines in my picture. I've updated the picture to remove the redlines. – Daniel Kaplan Sep 19 '23 at 23:33an errant piece of software could be trying to drive the wrong audio device and as a result be glitching your audio for youIs this a common occurrence? Is it like flipping a coin were being struck by lightning? – Daniel Kaplan Sep 19 '23 at 23:35Personally I'd be tempted to take a backup of my OS and do a clean install to rule out that sideActually I did that roughly 2 weeks ago. The problem reappeared. A new headset is in the mail. Call me a pessimist, but I don't expect the new headset to fix the problem. To me it seems like a software issue since reinstalling drivers and changing the volume temporarily fixes it. But I'm not a hardware guy. Hopefully I'm wrong. – Daniel Kaplan Sep 19 '23 at 23:52