I'd suggest writing your own macro to place the sub-figure numbering:

\documentclass{revtex4-1}% http://ctan.org/pkg/ltxutil
\usepackage{graphicx}% http://ctan.org/pkg/graphicx
\newcommand{\subfigimg}[3][,]{%
\setbox1=\hbox{\includegraphics[#1]{#3}}% Store image in box
\leavevmode\rlap{\usebox1}% Print image
\rlap{\hspace*{10pt}\raisebox{\dimexpr\ht1-2\baselineskip}{#2}}% Print label
\phantom{\usebox1}% Insert appropriate spcing
}
\begin{document}
\begin{figure}
\centering
\begin{tabular}{@{}p{0.45\linewidth}@{\quad}p{0.45\linewidth}@{}}
\subfigimg[width=\linewidth]{A)}{example-image-a} &
\subfigimg[width=\linewidth]{B)}{example-image-b} \\
\subfigimg[width=\linewidth]{C)}{example-image-c} &
\subfigimg[width=\linewidth]{D)}{example-image-a}
\end{tabular}
\caption{A caption}
\end{figure}
\end{document}
Once you have the image, you can print it in a box and extract its dimensions in order to use them to position the label.
The above macro \subfigimg[<options>]{<label>}{<image>} does exactly that. It inserts <image> with options <options> and imprints the <label> 10pt from the left and 2 baseline skips from the top of the image.
No packages nor tomfoolery. Just box manipulation.
Some added flair with string comparison for positioning...
pdfTeX introduced \pdfstrcmp for string comparison in version 1.30:
\pdfstrcmp{<a>}{<b>} compares two strings and returns the strings "0"
if equals <b>, "-1" if <a> is less than <b>, "1" if <a> is greater
than <b>.

\documentclass{revtex4-1}% http://ctan.org/pkg/ltxutil
\usepackage{graphicx}% http://ctan.org/pkg/graphicx
\usepackage{xkeyval,xcolor}% http://ctan.org/pkg/{xkeyval,xcolor}
\makeatletter
\newlength{\sfp@hseplen}\newlength{\sfp@vseplen}
\define@cmdkey{subfigpos}[sfp@]{pos}[ul]{}% \sfp@pos
\define@cmdkey{subfigpos}[sfp@]{font}[\small]{}% \sfp@font
\define@cmdkey{subfigpos}[sfp@]{vsep}[2\baselineskip]{\setlength{\sfp@vseplen}{\sfp@vsep}}% \sfp@vsep
\define@cmdkey{subfigpos}[sfp@]{hsep}[10pt]{\setlength{\sfp@hseplen}{\sfp@hsep}}% \sfp@hsep
\newcommand{\subfigimg}[3][,]{%
\setkeys{Gin,subfigpos}{pos,font,vsep,hsep,#1}% Set (default) keys
\setbox1=\hbox{\includegraphics{#3}}% Store image in box
\ifnum\pdfstrcmp{\sfp@pos}{ul}=0% UPPER LEFT placement of subfig label
\leavevmode\rlap{\usebox1}% Print image
\rlap{\hspace*{\sfp@hsep}\raisebox{\dimexpr\ht1-\sfp@vsep}{\sfp@font{#2}}}% Print label
\phantom{\usebox1}% Insert appropriate spacing
\else\ifnum\pdfstrcmp{\sfp@pos}{ur}=0% UPPER RIGHT placement of subfig label
\leavevmode\usebox1% Print image
\llap{\raisebox{\dimexpr\ht1-\sfp@vsep}{\sfp@font{#2}}\hspace*{\sfp@hsep}}% Print label
\else\ifnum\pdfstrcmp{\sfp@pos}{lr}=0% LOWER RIGHT placement of subfig label
\leavevmode\usebox1% Print image
\llap{\raisebox{\sfp@vsep}{\sfp@font{#2}}\hspace*{\sfp@hsep}}% Print label
\else% Assume LOWER LEFT placement of subfig label
\leavevmode\rlap{\usebox1}% Print image
\rlap{\hspace*{\sfp@hseplen}\raisebox{\sfp@vsep}{\sfp@font{#2}}}% Print label
\phantom{\usebox1}% Insert appropriate spacing
\fi\fi\fi
}
\makeatother
\begin{document}
\begin{figure}
\centering
\begin{tabular}{@{}p{0.45\linewidth}@{\quad}p{0.45\linewidth}@{}}
\subfigimg[width=\linewidth,pos=lr]{A)}{example-image-a} &
\subfigimg[width=\linewidth,pos=ll,font=\color{green!30!red}]{B)}{example-image-b} \\
\subfigimg[width=\linewidth,pos=ur,font=\LARGE]{C)}{example-image-c} &
\subfigimg[width=\linewidth,pos=ul]{D)}{example-image-a}
\end{tabular}
\caption{A caption}
\end{figure}
\end{document}
The above MWE adds the keys pos, font, hsep and vsep to the mix. In turn they allow for selecting the position of the label, which font to use, the horizontal separation and vertical separation.
stackenginepackage. – Leo Fang Aug 18 '13 at 17:31