todonotes
As mentioned in \marginpar and \begin{align} \marginpar that is used by todonotes doesn't work inside align, but \marginnote from the marginnote package does. Hence, you could redefine a command from todonotes to use marginnote, and it works. Three compilation passes is needed.

\documentclass{report}
\usepackage{amssymb,amsmath}
\usepackage{todonotes}
\usepackage{marginnote}
\makeatletter
\renewcommand{\@todonotes@drawMarginNoteWithLine}{%
\begin{tikzpicture}[remember picture, overlay, baseline=-0.75ex]%
\node [coordinate] (inText) {};%
\end{tikzpicture}%
\marginnote[{% Draw note in left margin
\@todonotes@drawMarginNote%
\@todonotes@drawLineToLeftMargin%
}]{% Draw note in right margin
\@todonotes@drawMarginNote%
\@todonotes@drawLineToRightMargin%
}%
}
\makeatother
\begin{document}
\begin{align}
a^2&=b^2+c^2 \todo{check this calculation}
\end{align}
\end{document}
luatodonotes
If you're using lualatex to compile your documents, then replacing todonotes with luatodonotes is another option.
(Note (for TeX Live 2015 users at least): at the moment there is a problem with luatex.sty, which is loaded by luatodonotes, so a small patch suggested by David Carlisle in chat is
required.)

% ---------
% temporarily required
\makeatletter
\@namedef{ver@luatex.sty}{}
\makeatother
% ----------
\documentclass{report}
\usepackage{amsmath}
\usepackage{luatodonotes}
\begin{document}
\begin{align}
a^2&=b^2+c^2 \todo{check this calculation}
\end{align}
\end{document}
\marginparso no, I don't think it is possible to do that. Can't tell you the exact reason though. But on page 14 in the manual (if on Windows 7, Ubuntu and maybe OS X: search for todonotes.pdf) is some alternative: wrap it around thealignenvironment. – henry Sep 09 '13 at 17:55\text{\todo[inline]{check this calculation}}– doncherry Sep 09 '13 at 18:10