Using some ideas from Three-columns text with figures of 2\columnwidth, flowfram can assist in flowing your text around images in a specific (recti-linear) layout:

\documentclass{a0poster}% http://ctan.org/pkg/a0poster
\usepackage[landscape,margin=1cm]{geometry}% http://ctan.org/pkg/geometry
\usepackage{flowfram,graphicx,microtype}% http://ctan.org/pkg/{flowfram,graphicx,microtype}
\usepackage{lipsum}% http://ctan.org/pkg/lipsum
\newlength{\blockwidth}\setlength{\blockwidth}{.24\textwidth}
\setlength{\columnsep}{\dimexpr.01333\textwidth}
\newlength{\imageheight}\setlength{\imageheight}{.3\textheight}
\newflowframe{0.24\textwidth}{\textheight}
{0pt}{0pt}[columnone]
\newflowframe{0.24\textwidth}{\dimexpr.5\textheight-.5\imageheight-\columnsep}
{\dimexpr\blockwidth+\columnsep}{\dimexpr.5\textheight+.5\imageheight+\columnsep}[columntwoTOP]
\newflowframe{0.24\textwidth}{\dimexpr.5\textheight-.5\imageheight-\columnsep}
{\dimexpr\blockwidth+\columnsep}{0pt}[columntwoBOT]
\newflowframe{0.24\textwidth}{\dimexpr.5\textheight-.5\imageheight-\columnsep}
{\dimexpr2\blockwidth+2\columnsep}{\dimexpr.5\textheight+.5\imageheight+\columnsep}[columnthreeTOP]
\newflowframe{0.24\textwidth}{\dimexpr.5\textheight-.5\imageheight-\columnsep}
{\dimexpr2\blockwidth+2\columnsep}{0pt}[columnthreeBOT]
\newflowframe{0.24\textwidth}{\textheight}
{\dimexpr3\blockwidth+3\columnsep}{0pt}[columnfour]
\newstaticframe{\dimexpr2\blockwidth+\columnsep}{\imageheight}
{\dimexpr\blockwidth+\columnsep}{\dimexpr.5\textheight-.5\imageheight}[centerfigure]
\title{\textbf{Flowfram poster}}
\author{by Me}
\date{\today}
\begin{document}
\maketitle
\lipsum[1]
\begin{staticcontents*}{centerfigure}
\includegraphics[
width=\dimexpr2\blockwidth+\columnsep,
height=\imageheight]{example-image-a}
\end{staticcontents*}
\lipsum[2-33]
\end{document}
The above MWE creates 6 dynamic frames (columnone and columntwo span the entire \textheight, while columntwoTOP/BOT and columnthreeTOP/BOT span whatever's left after inserting the image. Technically, all you need to do is change the height of the image (set \imageheight), and everything else should fall into place. Of course, I assume you're only inserting an image (not a caption as well, but that could be changed).
The image is contained inside a "static frame" called centerfigure that spans exactly 2 columns (including the column separation/gap).