Only with tikz and the fit and matrix libraries. I also used backgrounds library for highlighting in the background (and does not cover the numbers).
\documentclass[border=1mm,tikz]{standalone}
\usetikzlibrary{fit,matrix,backgrounds}
\begin{document}
\begin{tikzpicture}
\matrix[matrix of math nodes,% Not strictly necessary but useful to put math symbols $...$
row sep=-\pgflinewidth,column sep=-\pgflinewidth,% Overlaps borders of the nodes
nodes={draw,minimum width=2em,minimum height=2em},inner sep=0.5ex] (mymatrix) {
50 & 0 & 150 & 200 \\
50 & 0 & 200 & 100 \\
100 & 0 & 250 & 200 \\
0 & 0 & 0 & 0 \\
};
\begin{pgfonlayer}{background}
\node[fill=blue!50,opacity=0.5,inner sep=-0.8ex,rounded corners=6pt,fit=(mymatrix-1-2)(mymatrix-4-2)] {};
\node[fill=blue!50,opacity=0.5,inner sep=-1ex,rounded corners=6pt,fit=(mymatrix-4-1)(mymatrix-4-4)] {};
\end{pgfonlayer}
\end{tikzpicture}
\end{document}
