
I wish to achieve following. There may be many variant of this.
If PDF annotations are okay for you:
\documentclass{article}
\usepackage{pdfcomment}
\newcommand*\callout[2]%
{%
\pdfmarkupcomment[color={ 0.3 0.3 0.3 },opacity=0]{\textbf{#1}}{#2}%
}%
\begin{document}
\callout{If}{If shows the cause ...} it can be detected ...
\end{document}

Tikz's callout library! See: https://tex.stackexchange.com/questions/146225/tikz-callout-shape-with-arrow or https://tex.stackexchange.com/questions/131012/notes-on-sentences/131013#131013
– Josef
Aug 28 '14 at 11:24