Initial question
Is there an easy way to vary the thickness of a path along its length to create a wedge (for instance, to create a stereochemical cue)?
e.g. cis-cyclohexane-1,2-diol, drawn in ACD/ChemSketch.

The expanding waves decorator looks perfect for receding bonds, but there is no listed equivalent for approaching bonds.
Playing with expanding waves decorator
Based on the thread that Jake linked, I had a look at variables that can be tweaked with the expanding waves decorator. I don't think the current PGF/TikZ manual explicitly mentions it, but the expanding waves decorator has a segment length variable, as used in this example - setting it to my linewidth of 0.4 pt yields a solid wedge.

As Jake points out, this is the Wrong Way to approach this problem for performance reasons.

expanding wavesdecorator, they could converge into a wedge... Trying this... – Richard Terrett Jun 30 '11 at 05:09