Your question is a bit unclear in stating what you actually want aligned, but here you go:
If you only want your 'small' and 'long' formulae centered horizontally in 1 equation, I presume it's easiest to use an array environment instead of an aligned environment.
Maybe aligned could be possible as well but (though this comes close: https://tex.stackexchange.com/a/38442/46716), I have no idea how to get a horizontal centered alignment in the right hand side of your formulae (second column in aligned).
So array it is:
\begin{align*}
\left.
\begin{array}{rc}
\text{odd pixel values } n: & \mathbf{Dark}\mathrm{[Bias]}_\frac{n+1}{2} \\
\text{even pixel values } n: & \dfrac{1}{2}\left(\mathbf{Dark}\mathrm{[Bias]}_\frac{n}{2} + \mathbf{Dark}\mathrm{[Bias]}_{\frac{n}{2}+1}\right) \\
\end{array}
\right\} &= \mathrm{Master-}\mathbf{Dark}\mathrm{[Bias]} \\
\\
\left.
\begin{array}{rc}
\text{odd pixel values } n: & \mathbf{Dark}_\mathbf{flat}\mathrm{[Bias]}_\frac{n+1}{2} \\
\text{even pixel values } n: & \dfrac{1}{2}\left(\mathbf{Dark}_\mathbf{flat}\mathrm{[Bias]}_\frac{n}{2} + \mathbf{Dark}_\mathbf{flat}\mathrm{[Bias]}_{\frac{n}{2}+1}\right) \\
\end{array}
\right\} &= \mathrm{Master-}\mathbf{Dark}_\mathbf{flat}\mathrm{[Bias]} \\
\end{align*}
If you want both your equations to be aligned as well, use the blkarray package:
\begin{blockarray}{rc}
\begin{block}{rc\Right{\}}{= Master-\textbf{Dark}[Bias]}}
odd pixel values $n$ : & \textbf{Dark}[Bias]$_\frac{n+1}{2}$ \\
even pixel values $n$ : & $\dfrac{1}{2}\left(\mathbf{Dark}\mathrm{[Bias]}_\frac{n}{2} + \mathbf{Dark}\mathrm{[Bias]}_{\frac{n}{2}+1}\right)$ \\
\end{block}
& \\
\begin{block}{rc\Right{\}}{= Master-\textbf{Dark}$_\mathbf{flat}$[Bias]}}
odd pixel values $n$ : & \textbf{Dark}$_\mathbf{flat}$[Bias]$_\frac{n+1}{2}$ \\
even pixel values $n$ : & $\dfrac{1}{2}\left(\mathbf{Dark}_\mathbf{flat}\mathrm{[Bias]}_\frac{n}{2} + \mathbf{Dark}_\mathbf{flat}\mathrm{[Bias]}_{\frac{n}{2}+1}\right)$ \\
\end{block}
\end{blockarray}
Take a look at this MWE to see the difference:

\documentclass{article}
\usepackage{amsmath}
\usepackage{blkarray}
\begin{document}
\begin{align*}
\left.
\begin{array}{rc}
\text{odd pixel values } n: & \mathbf{Dark}\mathrm{[Bias]}_\frac{n+1}{2} \\
\text{even pixel values } n: & \dfrac{1}{2}\left(\mathbf{Dark}\mathrm{[Bias]}_\frac{n}{2} + \mathbf{Dark}\mathrm{[Bias]}_{\frac{n}{2}+1}\right) \\
\end{array}
\right\} &= \mathrm{Master-}\mathbf{Dark}\mathrm{[Bias]} \\
\\
\left.
\begin{array}{rc}
\text{odd pixel values } n: & \mathbf{Dark}_\mathbf{flat}\mathrm{[Bias]}_\frac{n+1}{2} \\
\text{even pixel values } n: & \dfrac{1}{2}\left(\mathbf{Dark}_\mathbf{flat}\mathrm{[Bias]}_\frac{n}{2} + \mathbf{Dark}_\mathbf{flat}\mathrm{[Bias]}_{\frac{n}{2}+1}\right) \\
\end{array}
\right\} &= \mathrm{Master-}\mathbf{Dark}_\mathbf{flat}\mathrm{[Bias]} \\
\end{align*}
\vspace*{2cm}
\begin{blockarray}{rc}
\begin{block}{rc\Right{\}}{= Master-\textbf{Dark}[Bias]}}
odd pixel values $n$ : & \textbf{Dark}[Bias]$_\frac{n+1}{2}$ \\
even pixel values $n$ : & $\dfrac{1}{2}\left(\mathbf{Dark}\mathrm{[Bias]}_\frac{n}{2} + \mathbf{Dark}\mathrm{[Bias]}_{\frac{n}{2}+1}\right)$ \\
\end{block}
& \\
\begin{block}{rc\Right{\}}{= Master-\textbf{Dark}$_\mathbf{flat}$[Bias]}}
odd pixel values $n$ : & \textbf{Dark}$_\mathbf{flat}$[Bias]$_\frac{n+1}{2}$ \\
even pixel values $n$ : & $\dfrac{1}{2}\left(\mathbf{Dark}_\mathbf{flat}\mathrm{[Bias]}_\frac{n}{2} + \mathbf{Dark}_\mathbf{flat}\mathrm{[Bias]}_{\frac{n}{2}+1}\right)$ \\
\end{block}
\end{blockarray}
\end{document}