I have a very strange issue with Reledpar and Imakeidx. If you put the same object into the same index it gets duplicated if the entry is located in the Endonotes.
More strange, the issue appears just with names like {Pippo \textsc{iii}}, and not with single words names.
I already tried things like Pippo \textsc{iii}@Pippo \textsc{iii}, but it didn't work.
Here is a MWE:
\documentclass[10pt, twoside, openright]{book}
\usepackage{fontspec}
\newfontfamily\unicodefont{Garamond Premier Pro}
\newfontfamily\SlantedFont{Garamond Premier Pro}
\setmainfont[]{Garamond Premier Pro}
\newfontfamily\greekfont{Garamond Premier Pro}
\usepackage{polyglossia}
\setmainlanguage{italian}
\setotherlanguage[]{greek}
%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%% INDICI %%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%%
\usepackage{morewrites} % Risolve il problema di Reledmac con gli indici multipli
\usepackage{imakeidx}
\indexsetup{othercode=\footnotesize}
\makeindex[name=nomi, intoc=true, title=Indice dei nomi]
%%%%%%%%%%%%%%%%%%%%% COMANDI RELEDMAC / RELEDPAR %%%%%%%%%%%%%%%%%%%%%%
\usepackage[noledgroup, % Escludo l'uso di note dentro minipage
noeledsec, % Non uso comandi di sezionamento tipo chapter, section, etc all'interno del txt critico
series={A,B}]{reledmac} % Restringo le serie di note alle sole che uso
\usepackage[shiftedpstarts, nomaxlines]{reledpar} % settaggi di sincronia. % advancedshiftedpstarts
%%%%%%%%%%%%%%%%%%% INIZIO DOCUMENTO %%%%%%%%%%%%%%%%%%%%%%
\begin{document}
Pippo\index[nomi]{Pippo \textsc{iii}}
\cleardoublepage
\selectlanguage{greek}
\begin{pages}
\begin{Leftside}
\beginnumbering
\numberpstarttrue
\pagenumbering{arabic}
\setcounter{page}{2}
\pstart
Ἐν πολλοῖς μέν εἰσιν οἱ ἔλεγχοι \edtext{πολυστίχοις}{\Afootnote{πολιστίχοις }} \edtext{ἐσπαρμένοι}{\Afootnote{ἐπαρμένοι FP ἐγκατεσπαρμένοι J}} λόγοις, δι’ ὧν ἡ ὀφρὺς κατασπᾶται τῶν τὴν ἀλήθειαν ἐν ἀδικίᾳ κατέχειν φιλονεικούντων. \pend
\endnumbering
\end{Leftside}
\selectlanguage{italian}
\begin{Rightside}
\beginnumbering
\numberpstarttrue
\normalsize
\pstart
Hello my dear friend Pippo\index[nomi]{Pippo \textsc{iii}} you are a good, \edtext{friend}{\Bendnote{Pippo\textsc{\index[nomi]{Pippo \textsc{iii}}}}} and that's all.\pend
\endnumbering
\end{Rightside}
\end{pages}
\Pages
\doendnotes{B}
\printindex[nomi]
\end{document}
makeindex's-cswitch might help. – Nicola Talbot Apr 16 '18 at 18:07