Before trying it, I thought \framezoom would make slides that looked something like this workaround:
\documentclass{beamer}
\usepackage{tikz}
\usepackage{graphicx}
\setbeamertemplate{navigation symbols}{}
\title{Zoomed Image}
\begin{document}
\begin{frame}
\titlepage
\end{frame}
\begin{frame}<1-2>[label=original]
\frametitle<1,3>{Image}
\frametitle<2>{Region of Interest}
\begin{center}
\begin{tikzpicture}
\node<1->[anchor=south west,inner sep=0] at (0,0) {\includegraphics[height=0.75\paperheight]{standardWheel} };
\draw<2>[red,ultra thick,rotate=53] (5.4,-0.4) ellipse (32pt and 18pt);
\end{tikzpicture}
\end{center}
\end{frame}
\begin{frame}{Caliper}
\begin{center}
\includegraphics[trim=800 900 1500 600,clip,height=0.75\paperheight]{standardWheel}
\end{center}
\end{frame}
\againframe<3->{original}
\begin{frame}{Next Slide}
This is the next slide.
\end{frame}
Please note that when you navigate through the resulting slides, you see the full image, (then the image with the Tikz drawing), then the zoomed image, then the full image, then the next slide. I tried a bunch of different things with \framezoom but I couldn't get any of them to navigate like that. The closest I was able to get was:
\documentclass{beamer}
\usepackage{graphicx}
\setbeamertemplate{navigation symbols}{}
\title{Zoomed Image}
\begin{document}
\begin{frame}
\titlepage
\end{frame}
\begin{frame}<1-2>[label=original]{An Attempt}
\frametitle<1,3>{Image}
\frametitle<2>{Region of Interest}
\framezoom<1><2>[border](2.5cm,2cm)(2cm,2cm)
\begin{centering}
\includegraphics[height=0.75\paperheight]{standardWheel}
\end{centering}
\end{frame}
\againframe<3->{original}
\begin{frame}{Next Slide}
next slide
\end{frame}
\end{document}
Even if I navigate through the slides by clicking instead of using the keyboard, I always end up showing the enlarged image twice. Once by clicking the button that \framezoom creates, (then clicking the enlarged image to return to the original image), then again when I click the slide with the original image to navigate to my next slide (I have to navigate through the enlarged image to continue my presentation). Is this how \framezoom was intended to work? If I add additional zoom locations to the image, I'll have to navigate through all the enlarged images to continue my presentation. I don't get it.
EDIT: Alternatively, does anyone know how to override the page down/arrow/click anywhere (as opposed to making a button hyperlink) command for one slide? Then I could set the target to the slide after the zoomed images.
The image is a JPG but this is just a test - when I put it into my presentation I intend to use an EPS. I'm compiling with pdflatex and using acroread to view since my version of evince (2.28.1) can't follow the zoomed image link back to the original image.

beamerinternals, but answering these questions helps me a lot :-) – diabonas Mar 29 '12 at 17:15\againframein the appendix/backup slides? – aeroNotAuto Apr 02 '12 at 05:00beamerhyperlinks them correctly. – diabonas Apr 02 '12 at 06:48