Lucida Bright has unusually large x-height; it is 5.3pt, compared to 4.31pt of Latin Modern. The height of uppercase glyphs is 7.23pt, while Latin Modern has 6.83pt.
Thus a 10/12 setting is surely not suitable for unscaled Lucida Bright; in general I prefer to load them scaled at 85%, which gives a x-height of 4.5pt and height of uppercase letters 6.15pt (yes, in Lucida Bright the lowercase letters are pretty high, compared to uppercase ones).
However, if letters with ornaments appear, the problem of uniform baselines still comes out.
In the AMS classes, a setting of 10/13 is used, and one of the reasons is quite certainly the fact that accented symbols are frequent in mathematical documents. Here's a comparison:
\documentclass{article}
\usepackage{unicode-math}
\setmainfont[Scale=.85]{Lucida Bright OT}
\setmathfont[Scale=.85]{Lucida Bright Math OT}
\newfontface\luc{Lucida Bright OT}
\begin{document}
Setting is 10/12
\medskip
Some text just to show the effect when some large symbol
is inline and some text just to show the effect when
some large symbol is inline; here it is $\widetilde{\beta}$
and some text follows and some text follows and some text follows
and some text follows and some text follows.
\bigskip
\linespread{1.08333}\normalsize %\baselineskip=13pt
Setting is 10/13
\medskip
Some text just to show the effect when some large symbol
is inline and some text just to show the effect when
some large symbol is inline; here it is $\widetilde{\beta}$
and some text follows and some text follows and some text follows
and some text follows and some text follows.
\end{document}
In the second paragraph I use a 10/13 setting and the lines are equally spaced.

I wouldn't bother too much for the occasional enlargement of one baseline skip; but probably the adjustment is worthy a try. Just put
\linespread{1.08333}
in your preamble. You probably will need also to change slightly the text height to ensure an integer number of lines. The geometry package can do it with the key heightrounded. The baseline skip should be increased something more than 13pt if you prefer unscaled Lucida.
$\smash{\widetilde{f}}$an option? – Dec 12 '12 at 17:33