Here's some possibility using the titlesec package and a font admitting large sizes; adjust the settings according to your needs:
\documentclass{book}
\usepackage[explicit]{titlesec}
\usepackage{lmodern}
\usepackage{lipsum}
\newlength\chapnumb
\setlength\chapnumb{4cm}
\titleformat{\chapter}[block]
{\normalfont\sffamily}{}{0pt}
{\parbox[b]{\chapnumb}{%
\fontsize{120}{110}\selectfont\thechapter}%
\parbox[b]{\dimexpr\textwidth-\chapnumb\relax}{%
\raggedleft%
\hfill{\LARGE#1}\\
\rule{\dimexpr\textwidth-\chapnumb\relax}{0.4pt}}}
\titleformat{name=\chapter,numberless}[block]
{\normalfont\sffamily}{}{0pt}
{\parbox[b]{\chapnumb}{%
\mbox{}}%
\parbox[b]{\dimexpr\textwidth-\chapnumb\relax}{%
\raggedleft%
\hfill{\LARGE#1}\\
\rule{\dimexpr\textwidth-\chapnumb\relax}{0.4pt}}}
\begin{document}
\chapter*{A Long Title for an Unnumbered Test Chapter}
\lipsum[4]
\chapter{Introduction}
\lipsum[4]
\end{document}
An image for an unnumbered (starred) chapter:

An image for a numbered chapter:
