I am having some layout issues with beamerposter. As you can see the vertical alignment does not work properly. Also, the conclusions block is too long.

\documentclass[final]{beamer}
\mode<presentation>
{
\usetheme{Berlin}
}
\usepackage[orientation=landscape,size=custom,width=200,height=120,scale=2.4,debug]{beamerposter}
\begin{document}
\begin{frame}[t]{}
\begin{columns}[totalwidth=\textwidth]
%% 1 column
\begin{column}{0.32\textwidth}
\begin{block}{Problem}
\end{block}
\end{column}
%% 2 column
\begin{column}{0.63\textwidth}
\begin{columns}[totalwidth = \textwidth]
\begin{column}{0.47\textwidth}
\begin{block}{Column 1}
\end{block}
\end{column}
%%
\begin{column}{0.47\textwidth}
\begin{block}{Column 2}
\end{block}
\end{column}
\end{columns}
\begin{block}{Conclusion}
\end{block}
\end{column}
\end{columns}
\end{frame}
\end{document}