Package mathtools provides the vertical alignments top, center, and bottom:
\documentclass{report}
\usepackage{amsmath}
\usepackage{mathtools}
\begin{document}
\makeatletter
\setlength{\@tempdimc}{\the\textwidth}
\settowidth{\@tempdima}{\hspace{2em}(\ref{equationA})}
\addtolength{\@tempdimc}{-\the\@tempdima}
\edef\somelength{\the\@tempdimc}
\makeatother
\begin{align}
& \framebox[0.8\linewidth]{\strut} \\
= & \!%
\begin{multlined}[t][\somelength]
\framebox[0.55\linewidth]{\strut} \\
\framebox[0.55\linewidth]{\strut}
\end{multlined} \label{equationA} \\
= & \!%
\begin{multlined}[c][\somelength]
\framebox[0.55\linewidth]{\strut} \\
\framebox[0.55\linewidth]{\strut}
\end{multlined} \label{equationB} \\
= & \!%
\begin{multlined}[b][\somelength]
\framebox[0.55\linewidth]{\strut} \\
\framebox[0.55\linewidth]{\strut}
\end{multlined} \label{equationC} \\
= & \framebox[0.8\linewidth]{\strut}
\end{align}
\end{document}

What I would like to get is top alignment regarding "=" and bottom alignment regarding the "\label" (number 2 in the following example):

How can this be achieved?

amsmathexplicitly; it is already loaded bymathtools. – Svend Tveskæg Dec 06 '13 at 14:01multlined, it only handles contents, not where the equation number is placed in relation to that content (that is handled by the outer env, herealign). – daleif Dec 06 '13 at 14:51