An alternative where varwidth package and a dummy frame are used, to achieve the desired layout given by the OP.

Code
\documentclass{article}
\usepackage{subfigure}
\usepackage{varwidth,xcolor}
\usepackage[demo]{graphicx}
\usepackage[margin=1cm]{geometry}
\begin{document}
\begin{figure}[!h]
\centering
\begin{varwidth}{0.5\linewidth} % this is a must
\subfigure[Frame 1]{\includegraphics[width=4cm]{im1.png}}\\
\subfigure[Frame 2]{\includegraphics[width=4cm]{im2.png}}
\end{varwidth}
\begin{varwidth}{0.5\linewidth} % this is a must
\subfigure[Frame 3]{\includegraphics[width=4cm]{im1.png}}
\subfigure[Frame 4]{\includegraphics[width=4cm]{im2.png}}\\
\color{white}
\subfigure[Dummy Frame]{\includegraphics[draft,width=4cm]{dummy}}
\color{black}
\end{varwidth}
\caption{caption.}
\label{farraypicture}
\end{figure}
\end{document}
Edit: Suggested by Harish Kumar due to depreciated package, here subcaption along with caption packages are used.

and this is the code for the image above. (Both subcaptonbox command and subfigure environments are presented.)
\documentclass{article}
\usepackage{subcaption}
\usepackage{caption}
\usepackage{varwidth,xcolor}
\usepackage[demo]{graphicx}
\usepackage[margin=1cm]{geometry}
\captionsetup[figure]{labelfont=it,textfont={bf,it},labelsep=none}
\renewcommand{\thesubfigure}{(\alph{subfigure})~}
\renewcommand{\thefigure}{\arabic{figure}: }
\begin{document}
Use of subfloat command
\begin{figure}[!h]
\centering
\begin{varwidth}{0.33\linewidth} % this is a must
\subcaptionbox{Frame 1}{\includegraphics[width=4cm]{im1.png}}
\subcaptionbox{Frame 2}{\includegraphics[width=4cm]{im2.png}}\\
\end{varwidth}\quad\quad
\begin{varwidth}{0.66\linewidth} % this is a must
\subcaptionbox{Frame 3}{\includegraphics[width=4cm]{im3.png}}\quad\quad
\subcaptionbox{Frame 4}{\includegraphics[width=4cm]{im4.png}}\\
\begin{subfigure}{1in}
\color{white}
\includegraphics[width=1in]{dummy}
\caption*{}
\color{black}
\end{subfigure}
\end{varwidth}
\caption{caption}
\label{arraypicture}
\end{figure}
Use of subfigure environment
\begin{figure}[!h]
\centering
\begin{varwidth}{0.33\linewidth} % this is a must
\begin{subfigure}{4cm}
\includegraphics[width=4cm]{im1.png}
\caption{Frame 1}
\end{subfigure}\\
\begin{subfigure}{4cm}
{\includegraphics[width=4cm]{im2.png}}
\caption{Frame 2}
\end{subfigure}
\end{varwidth}\quad\quad
\begin{varwidth}{0.66\linewidth} % this is a must
\begin{subfigure}{4cm}
\includegraphics[width=4cm]{im3.png}
\caption{Frame 3}
\end{subfigure}\quad\quad
\begin{subfigure}{4cm}
{\includegraphics[width=4cm]{im4.png}}
\caption{Frame 4}
\end{subfigure}\\
\begin{subfigure}{1in}
\color{white}
\includegraphics[width=1in]{dummy}
\caption*{}
\color{black}
\end{subfigure}
\end{varwidth}
\caption{caption}
\label{arraypicture}
\end{figure}
\end{document}
multirowis not necessary, as can already be seen by answers on the linked question and now also to your question. Next time you ask a question add, please, a minimal working example (MWE) that illustrates your problem. It will be much easier for us to reproduce your situation and find out what the issue is when we see compilable code, starting with\documentclass{...}and ending with\end{document}. – Speravir Jan 30 '14 at 01:41