Here is an adaption of Draw a line through one column of a matrix:

Notes:
- This does require two runs. First one to determine the locations, and the second to do the drawing.
- Another option is to use the
tikzmark package, but for this particular case it is simpler to not use that package: The custom defined \MyTikzmark provides anchor points .north and .south which are automatically centered vertically. Similarly .east and .west are centered vertically. In the tikzmark package version the lines were extended via shorten >= and shorten <= and shifted using yshift to provide similar results.
Code: Without tikzmark package.
\documentclass{article}
\usepackage{amsmath}
\usepackage{tikz}
\newcommand{\MyTikzmark}[2]{%
\tikz[overlay,remember picture,baseline] \node [anchor=base] (#1) {$#2$};%
}
\newcommand{\DrawVLine}[3][]{%
\begin{tikzpicture}[overlay,remember picture]
\draw[shorten <=0.3ex, #1] (#2.north) -- (#3.south);
\end{tikzpicture}
}
\newcommand{\DrawHLine}[3][]{%
\begin{tikzpicture}[overlay,remember picture]
\draw[shorten <=0.2em, #1] (#2.west) -- (#3.east);
\end{tikzpicture}
}
\begin{document}
[
\begin{bmatrix}
\MyTikzmark{leftA}{15} & 0 & \MyTikzmark{topB}{0} & \MyTikzmark{rightA}{0} \
0 & 50 & 20 & 25 \
35 & 5 & 0 & 10 \
\MyTikzmark{bottomA}{0} & 65 & \MyTikzmark{bottomB}{50} & 65
\end{bmatrix}
]
\DrawVLine[red, thick, opacity=0.5]{leftA}{bottomA}
\DrawVLine[orange, thick, opacity=0.5]{topB}{bottomB}
\DrawHLine[blue, thick, opacity=0.5]{leftA}{rightA}
\end{document}
Code: With tikzmark package.
\documentclass{article}
\usepackage{amsmath}
\usepackage{tikz}
\usetikzlibrary{calc,tikzmark}
\newcommand{\MyTikzmark}[2]{%
\tikz[remember picture,baseline]
\node [anchor=base, inner sep=0pt, outer sep=0pt]
{\tikzmark{#1 LEFT}$#2$\tikzmark{#1 RIGHT}};%
}
\newcommand{\DrawVLine}[3][]{%
\begin{tikzpicture}[overlay,remember picture]
\draw[shorten <=-1.7ex, shorten >=-0.3ex, #1]
($(pic cs:#2 LEFT)!0.5!(pic cs:#2 RIGHT)$) --
($(pic cs:#3 LEFT)!0.5!(pic cs:#3 RIGHT)$);
\end{tikzpicture}
}
\newcommand{\DrawHLine}[3][]{%
\begin{tikzpicture}[overlay,remember picture]
\draw[shorten <=-0.2em, shorten >=-0.3em, yshift=0.7ex, #1]
(pic cs:#2 LEFT) -- (pic cs:#3 RIGHT);
\end{tikzpicture}
}
\begin{document}
[
\begin{bmatrix}
\MyTikzmark{leftA}{15} & 0 & \MyTikzmark{topB}{0} & \MyTikzmark{rightA}{0} \
0 & 50 & 20 & 25 \
35 & 5 & 0 & 10 \
\MyTikzmark{bottomA}{0} & 65 & \MyTikzmark{bottomB}{50} & 65
\end{bmatrix}
]
\DrawVLine[red, thick, opacity=0.5]{leftA}{bottomA}
\DrawVLine[orange,thick, opacity=0.5]{topB}{bottomB}
\DrawHLine[blue, thick, opacity=0.5]{leftA}{rightA}
\end{document}
\tikzmark? – egreg Mar 28 '15 at 19:03tikzmarkpackage version, but for this case I think it is easier to not use the package. See "Notes" section. Apologies for the delay in responding. – Peter Grill Apr 06 '15 at 02:30