I have heard that LaTeX is not necessarily suited to make panels. That even two-column is difficult to get the text to align. I would like to draw stuff like this:
---------------------------
|________________|________|
|________|________________|
Using rectangles of appropriate dimension. Here is a better example.

I was thinking of trying with Tikz and using their nodes... I don't know if that's possible or if there is even easier way.
Here is what I tried. The rectangles don't align properly.
\begin{tikzpicture}[xshift=-0.5in]
\node[draw,thick,rectangle,fill=blue!20, text width=3in, align=left] at (0,0){ \begin{minipage} [t][3in]{3in} $\int$ $\partial$. \end{minipage}};
\node[draw,thick,rectangle,fill=blue!20, text width=3in, align=left] at (3.25in,0.25in) { \begin{minipage} [t][3in]{2in} $\int$ $\partial$. \end{minipage}};
\node[draw,thick,rectangle,fill=blue!20, text width=3in, align=left] at (0,3.25in) { \begin{minipage} [t][3in]{3in} $\int$ $\partial$. \end{minipage}};
\node[draw,thick,rectangle,fill=blue!20, text width=3in, align=left] at (3.25in,3.25in) { \begin{minipage} [t][3in]{2in} $\int$ $\partial$. \end{minipage}};
\end{tikzpicture}


flowframpackage which does this kind of things easily. – Sep 07 '14 at 11:46