I am using Adobe Minion Pro (mostly because of its maths support), but I don't want to use the 'Th' ligature. This decision is based on guidance from Bringhurst's Elements of Typographic Style.
I have tried using microtype to disable any ligatures starting with 'T', but this also seems to affect kerning pairs starting with 'T'. Here is a working example:
\documentclass{article}
\usepackage{minionpro}
\usepackage{microtype}
%\DisableLigatures[T]{}
\begin{document}
Th
To
\end{document}
When I don't modify the default behaviour of microtype, the output looks like this

But when I uncomment \DisableLigatures[T]{}, I get this output:

This separates the 'Th' ligature successfully, but is no longer any kerning on 'To' (kerning for other characters appears to be unaffected).
How do I disable the 'Th' ligature without interfering with the kerning?

\Th. When you end your document, and you are going to send/print it, just do a Search forTh& Replace for\Th(with a trailing space) and that's all. – Manuel Jan 19 '15 at 00:37\Thmacro is a good idea. I should mention that many of my sentences begin with 'The', so the ligature is actually quite common in my documents. Perhaps this is a problem with my writing style, rather than LaTeX! – onewhaleid Jan 19 '15 at 00:52\makeatletter \newcommand*\Th{T\penalty\@M\hskip\z@ h} \makeatother. – Manuel Jan 19 '15 at 00:53\DisableLigatures[f]{}the kerning between the pair 'fe' is still definitely negative (although it is reduced by a whisker). – onewhaleid Jan 19 '15 at 04:01pdftex(inherited fromtexitself): information on ligatures and on kerning is stored in the same table in the font metrics, therefore one cannot switch off ligatures or kerning independently from one another. – Robert Jan 19 '15 at 04:38