Using the listofitems package, here is a homemade key-value interface that can handle an arbitrary number of specified values in the \input file. If that is overkill, one of the original approaches that follow should suffice.
\documentclass[letterpaper,10pt]{article}
\usepackage{filecontents,listofitems}
\begin{filecontents*}{boilerplate.tex}
I am excited to apply for the position of [POSITION] at [PLACE]. Your organization's
reputation for rigorous, high-quality programming on topics in align perfectly with
my ambitions. I would relish the opportunity to collaborate with top coders on our
shared interests in [INTERESTS]. I am committed to excellence in programming
and supporting the Chicago Cubs.
\end{filecontents*}
\catcode`[=\active %
\def[#1]{\csname #1\endcsname{}}%
\catcode`[=12 %
\newcommand\myinput[2]{%
\setsepchar{,}%
\readlist*\mydata{#2}%
\foreachitem\myvardef\in\mydata{%
\setsepchar{=}%
\readlist*\myvar{\myvardef}%
\expandafter\edef\csname\myvar[1]\endcsname{\myvar[2]}%
}%
\catcode`[=\active %
\input{#1}%
\catcode`[=12 %
}
\begin{document}
Dear So and So,
\myinput{boilerplate}{POSITION=engineer, PLACE=IBM, INTERESTS=omphaloskepsis}
\end{document}

ORIGINAL APPROACHES
\documentclass[letterpaper,10pt]{article}
\usepackage{filecontents}
\begin{filecontents*}{boilerplate.tex}
I am excited to apply for the position of \POSITION{} at \PLACE{}. Your organization's
reputation for rigorous, high-quality programming on topics in align perfectly with
my ambitions. I would relish the opportunity to collaborate with top coders on our
shared interests in \INTERESTS{}. I am committed to excellence in programming
and supporting the Chicago Cubs.
\end{filecontents*}
\newcommand\myinput[4]{%
\def\POSITION{#2}%
\def\PLACE{#3}%
\def\INTERESTS{#4}%
\input{#1}%
}
\begin{document}
Dear So and So,
\myinput{boilerplate}{engineer}{IBM}{omphaloskepsis}
\end{document}

And if one really wanted to use bracketed delimiters in the input file, then this works (EDITED to allow arbitrary number of comma separated arguments in #2):
\documentclass[letterpaper,10pt]{article}
\usepackage{filecontents,listofitems}
\begin{filecontents*}{boilerplate.tex}
I am excited to apply for the position of [POSITION] at [PLACE]. Your organization's
reputation for rigorous, high-quality programming on topics in align perfectly with
my ambitions. I would relish the opportunity to collaborate with top coders on our
shared interests in [INTERESTS]. I am committed to excellence in programming
and supporting the Chicago Cubs, [FOUR], [FIVE], [SIX], [SEVEN], [EIGHT], [NINE],
and [TEN].
\end{filecontents*}
\catcode`[=\active %
\def[#1]{\csname #1\endcsname{}}%
\catcode`[=12 %
\newcommand\myinput[2]{%
\setsepchar{,}%
\readlist*\mydata{#2}%
\def\POSITION{\mydata[1]}%
\def\PLACE{\mydata[2]}%
\def\INTERESTS{\mydata[3]}%
\def\FOUR{\mydata[4]}%
\def\FIVE{\mydata[5]}%
\def\SIX{\mydata[6]}%
\def\SEVEN{\mydata[7]}%
\def\EIGHT{\mydata[8]}%
\def\NINE{\mydata[9]}%
\def\TEN{\mydata[10]}%
\catcode`[=\active %
\input{#1}%
\catcode`[=12 %
}
\begin{document}
Dear So and So,
\myinput{boilerplate}{engineer,IBM,omphaloskepsis, Orioles, Red Sox, Cardinals,
Phillies, Tigers, Blue Jays, Braves}
\end{document}
