I use morsbug's code to generate an isbn barcode. It works fine, at least as long as I provide the isbn as a string.
If I pass the isbn number using a variable defined by \newcommand{\isbn}{123...} the compilation fails.
The following MWE should demonstrate the goal:
\documentclass{article}
\def\barcode#1#2#3#4#5#6#7{\begingroup%
\dimen0=0.1em
\def\stack##1##2{\oalign{##1\cr\hidewidth##2\hidewidth}}%
\def\0##1{\kern##1\dimen0}%
\def\1##1{\vrule height10ex width##1\dimen0}%
\def\L##1{\ifcase##1\bc3211##1\or\bc2221##1\or\bc2122##1\or\bc1411##1%
\or\bc1132##1\or\bc1231##1\or\bc1114##1\or\bc1312##1\or\bc1213##1%
\or\bc3112##1\fi}%
\def\R##1{\bgroup\let\next\1\let\1\0\let\0\next\L##1\egroup}%
\def\G##1{\bgroup\let\bc\bcg\L##1\egroup}% reverse
\def\bc##1##2##3##4##5{\stack{\0##1\1##2\0##3\1##4}##5}%
\def\bcg##1##2##3##4##5{\stack{\0##4\1##3\0##2\1##1}##5}%
\def\bcR##1##2##3##4##5##6{\R##1\R##2\R##3\R##4\R##5\R##6\11\01\11\09%
\endgroup}%
\stack{\09}#1\11\01\11\L#2%
\ifcase#1\L#3\L#4\L#5\L#6\L#7\or\L#3\G#4\L#5\G#6\G#7%
\or\L#3\G#4\G#5\L#6\G#7\or\L#3\G#4\G#5\G#6\L#7%
\or\G#3\L#4\L#5\G#6\G#7\or\G#3\G#4\L#5\L#6\G#7%
\or\G#3\G#4\G#5\L#6\L#7\or\G#3\L#4\G#5\L#6\G#7%
\or\G#3\L#4\G#5\G#6\L#7\or\G#3\G#4\L#5\G#6\L#7%
\fi\01\11\01\11\01\bcR}
\begin{document}
\barcode 7046260816138 %<-- compilation succeeds
\newcommand{\isbn}{7046260816138}
%\barcode {\isbn} %<-- compilation fails
\end{document}
