Two examples where the desired result is obtained without knowing node dimensions. The second one uses calc tikzlibrary
\documentclass{standalone}
\usepackage{tikz}
\usetikzlibrary{calc}
\begin{document}
\begin{tikzpicture}
\node(a) {
\includegraphics[width=0.8\textwidth]{example-image-a}
};
\path (a.center)--(a.north) node[pos=.75, right] {label without calc};
\node[left] at ($(a.center)!.75!(a.north)$) {label with calc};
\end{tikzpicture}
\end{document}

Update:
Let's suppose we want the label label without calc 2cm to the right and 1cm up from its actual position in previous example: \path (a.center)--(a.north) node[pos=.75, right] {label without calc}. We can use positioning library to move the node relative to the corresponding point on path. In this case we can say above right=1cm and 2cm but this will use south west anchor for placement and we want west, then we add anchor=west after above right option:
\documentclass[border=2mm]{standalone}
\usepackage{tikz}
\usetikzlibrary{calc, positioning}
\begin{document}
\begin{tikzpicture}
\node[inner sep=0pt] (a) {
\includegraphics[width=0.8\textwidth]{example-image-a}
};
\path (a.center)--(a.north) node[draw, pos=.75, above right=1cm and 2cm, anchor=west, red] (b) {label without calc};
\node[left] (c) at ($(a.center)!.75!(a.north)$) {label with calc};
%Some auxiliary elements.
\draw[red,<->] (a.center)--(c.east) node[midway, right] {75\%};
\draw[red,<->] (c.east)--(a.north) node[midway,right] {25\%};
\fill[red] (c.east) circle (1pt);
\draw[red,<->] (c.east)-|(b.west) node[pos=0.25,below] {2 cm} node[pos=0.75,left] {1 cm};
\end{tikzpicture}
\end{document}

\node(b) at (a.south!1.25!a.north)might work. – Symbol 1 Jul 03 '17 at 09:28