I’m not sure I’ve understood what you want to do, but I’d go for something like this:
% My standard header for TeX.SX answers:
\documentclass[a4paper]{article} % To avoid confusion, let us explicitly
% declare the paper format.
\usepackage[T1]{fontenc} % Not always necessary, but recommended.
\usepackage[utf8]{inputenc} % Not always necessary, but recommended.
% End of standard header. What follows pertains to the problem at hand.
\usepackage{amsmath}
\begin{document}
An example:
\begin{equation}
\begin{split}
A &= \text{1st fairly large expr.}\cdot C \
&=\text{1st fairly large expr.} \cdot
\begin{aligned}[t]
& (\text{2nd fairly large expr.} \
& \quad + \text{3rd fairly large expr.})
\end{aligned}
\end{split}
\end{equation}
This assumes that you want to label the whole block with a single
equation number.
\end{document}
This is the output:

Another option
If you want each line to be numbered, use alignat:
% My standard header for TeX.SX answers:
\documentclass[a4paper]{article} % To avoid confusion, let us explicitly
% declare the paper format.
\usepackage[T1]{fontenc} % Not always necessary, but recommended.
\usepackage[utf8]{inputenc} % Not always necessary, but recommended.
% End of standard header. What follows pertains to the problem at hand.
\usepackage{amsmath}
\newcommand*{\myexpr}[1]{%
\langle\text{#1 fairly large expr.}\rangle
}
\begin{document}
An example:
\begin{equation}
\begin{split}
A &= \myexpr{1st} \cdot C \
&= \myexpr{1st} \cdot
\begin{aligned}[t]
& (\myexpr{2nd} \
& \quad + \myexpr{3rd})
\end{aligned}
\end{split}
\end{equation}
This assumes you want to label the whole block with a single equation number.
Individual lines can be numbered with the help of the \texttt{alignat}
environment:
\begin{alignat}{2}
A &= \myexpr{1st} && \cdot C \
&= \myexpr{1st}
&& \cdot (\myexpr{2nd} \notag \ % no number on this line
& && \mathbin{\hphantom{\cdot}} \quad {} + \myexpr{3rd})
\end{alignat}
We've also shown how to suppress the equation number on a particular line.
\end{document}
Note how the nature of binary operator of the phantom \cdot is preserved, so that it is properly spaced.
The output is:

&after the=. – GuM Apr 02 '18 at 01:45&means two columns of alignment, and these columns are separated by some length which is automatically inserted (this is the difference withalignat). – Bernard Apr 02 '18 at 09:50