You can issue \hss\egroup, that closes the box initiated by \line{\hss#1\hss}, and then \line\bgroup\hss to restart the business.
\def\cpar{\hss\egroup\line\bgroup\hss}
\centerline{A\cpar B\cpar CDEF\cpar Some more words}
\bye

Beware that a space before \cpar is not removed.
A different implementation using \\ and where spaces around items are trimmed off.
\input expl3-generic
\ExplSyntaxOn
\cs_set_eq:NN \atdot_centerline:n \centerline
\cs_set_protected_nopar:Npn \centerline #1
{
\seq_set_split:Nnn \l_atdotde_centerline_seq { \\ } { #1 }
\seq_map_inline:Nn \l_atdotde_centerline_seq
{
\atdot_centerline:n { ##1 }
}
}
\ExplSyntaxOff
\centerline{A \\ A\\ B \\ CDEF\\ Some more words}
\bye

My application is some newsletter program that announces talks. It reads information about the upcoming talks and typesets announcements. To this end, it centers the title with centerline and want the possibility for the inserted title to contain a macro that does the line breaking (while not giving up the entering). Of course, I could rewrite all ready the centerline using 69260 but I would prefer inserting a macro that tricks the above centerline as I indicated.
– atdotde Sep 26 '18 at 10:33