If you want to submit your paper to Elsevier (and this is the only good reason to use elsarticle.cls, I believe) you should follow their instructions as much as possible, use their template as-is and should definitely not modify it to use a package that is incompatible with the defaults loaded by the class (for elsarticle that would be natbib).
Publisher classes are usually meant to enable a simple and smooth workflow for the publisher. The workflow for citations and the bibliography with biblatex is significantly different from the workflow with BibTeX. For starters biblatex does not produce typesettable TeX code in a thebibliography environment. That means that publishers, whose workflow uses \bibitem/thebibliography as produced by BibTeX or used in manual bibliographies, will in all likeliness not be able to process submissions with biblatex bibliographies properly. See also Biblatex: submitting to a journal.
It is possible to make elsarticle use biblatex (see biblatex instead of natbib in elsarticle, how?), but I'm almost certain that Elsevier won't like that (cf. for example I cannot make my biblatex work). If you need something in your paper that the provided template can't do and that can't be implemented in a compatible way, you should contact the editor and ask for further instructions.
.bibdatabases? This would be step in the writer's workflow that occurs before citing a new work. – John Chris Jan 02 '19 at 13:27.bibfiles, see https://tex.stackexchange.com/q/84099/35864. If the publisher wants to you to upload the.bibfile and lets you upload several files that should work. If they want you to upload the.bbl, this is guaranteed to be OK. Of course you could also write a script to combine several.bibs into one larger.bib. But I'm not sure that is what you were thinking about. – moewe Jan 02 '19 at 15:49\def\bibnamea{<database a>}%and\def\bibnameb{<database b>}%in the preamble and my bibliography call looks like:\bibliography{bibnamea,bibnameb}%I can successfully reference citations from multiple databases using bibtex. Note that the database file name is the full filepath excluding the.bibextension. – John Chris Jan 02 '19 at 22:16